Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RAPGEF4 | Q8WZA2 | 3/20 | 0.49 |
| ▸ | HDAC3 | O15379 | 2/20 | 0.47 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.47 |
| ▸ | HDAC2 | Q92769 | 2/20 | 0.47 |
| ▸ | HDAC6 | Q9UBN7 | 2/20 | 0.47 |
| ▸ | SLC13A3 | Q8WWT9 | 1/20 | 0.38 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.37 |
| ▸ | SCN9A | Q15858 | 2/20 | 0.36 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.36 |
| ▸ | BRAF | P15056 | 1/20 | 0.36 |
| ▸ | RAPGEF3 | O95398 | 3/20 | 0.35 |
| ▸ | JUN | P05412 | 3/20 | 0.35 |
| ▸ | NFKB1 | P19838 | 3/20 | 0.35 |
| ▸ | NFKB2 | Q00653 | 3/20 | 0.35 |
| ▸ | RELA | Q04206 | 3/20 | 0.35 |
| ▸ | GRM4 | Q14833 | 1/20 | 0.35 |
| ▸ | AURKA | O14965 | 1/20 | 0.34 |
| ▸ | PIK3CG | P48736 | 1/20 | 0.34 |
| ▸ | XPO1 | O14980 | 1/20 | 0.34 |
| ▸ | ATF1 | P18846 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6237657 | 0.77 | AURKA (0.57) | RAPGEF4NFKB1GRM4AURKA | |
| SCHEMBL30041659 | 0.76 | EPHX2 (0.48) | SCN9A | |
| SCHEMBL6237353 | 0.74 | RAPGEF4 (0.49) | RAPGEF4GRM4 | |
| SCHEMBL17403481 | 0.72 | RAPGEF4 (0.46) | RAPGEF4HDAC3HDAC1HDAC2HDAC6 | |
| SCHEMBL6240725 | 0.72 | TDO2 (0.51) | BRAFGRM4 | |
| SCHEMBL6236093 | 0.70 | CDK4 (0.40) | SCN9ABRAF | |
| SCHEMBL16014245 | 0.68 | HDAC3 (0.48) | RAPGEF4HDAC3HDAC1HDAC2HDAC6 | |
| SCHEMBL4374429 | 0.68 | RAPGEF4 (0.53) | RAPGEF4HDAC3HDAC1HDAC2HDAC6 | |
| SCHEMBL12706897 | 0.68 | RAPGEF4 (0.57) | RAPGEF4HDAC3HDAC1HDAC2HDAC6 | |
| Hydrochloric Acid SCHEMBL4376336 | 0.66 | RAPGEF4 (0.51) | RAPGEF4HDAC3HDAC1HDAC2HDAC6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2005005382-A2 | COMPOUNDS, COMPOSITIONS AND METHODS | CYTOKINETICS, INC. (US) | 2005-01-20 | — | — | WO | disclosed |