Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 1/20 | 0.50 |
| ▸ | RAB9A | P51151 | 1/20 | 0.50 |
| ▸ | PPARD | Q03181 | 1/20 | 0.49 |
| ▸ | MAOB | P27338 | 1/20 | 0.48 |
| ▸ | FFAR1 | O14842 | 4/20 | 0.48 |
| ▸ | FFAR4 | Q5NUL3 | 4/20 | 0.48 |
| ▸ | SRD5A2 | P31213 | 1/20 | 0.48 |
| ▸ | HPD | P32754 | 2/20 | 0.47 |
| ▸ | RXRA | P19793 | 3/20 | 0.47 |
| ▸ | RXRB | P28702 | 2/20 | 0.47 |
| ▸ | NR1H2 | P55055 | 1/20 | 0.46 |
| ▸ | NR1H3 | Q13133 | 1/20 | 0.46 |
| ▸ | MTNR1B | P49286 | 1/20 | 0.45 |
| ▸ | PPARA | Q07869 | 1/20 | 0.45 |
| ▸ | GSK3B | P49841 | 1/20 | 0.44 |
| ▸ | BACE1 | P56817 | 1/20 | 0.44 |
| ▸ | RXRG | P48443 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6239626 | 0.84 | PTGDR2 (0.50) | PPARDMAOBFFAR1FFAR4SRD5A2 | |
| SCHEMBL6237398 | 0.81 | MAOB (0.57) | NPC1RAB9AMAOBHPDMTNR1B | |
| SCHEMBL3500758 | 0.80 | MAOB (0.63) | MAOBFFAR1FFAR4 | |
| SCHEMBL9659998 | 0.79 | FFAR1 (0.71) | PPARDMAOBFFAR1FFAR4SRD5A2 | |
| SCHEMBL8102862 | 0.79 | NPC1 (0.56) | NPC1RAB9AMAOBHPD | |
| SCHEMBL5835 | 0.77 | AKR1B1 (0.52) | — | |
| SCHEMBL29574729 | 0.77 | AKR1B1 (0.52) | — | |
| SCHEMBL6240357 | 0.77 | FFAR4 (0.47) | MAOBFFAR1FFAR4RXRARXRB | |
| SCHEMBL6241934 | 0.76 | POLB (0.56) | RAB9APPARDMAOBFFAR1FFAR4 | |
| SCHEMBL10565772 | 0.76 | RXRA (0.51) | MAOBFFAR1FFAR4RXRARXRB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2005009104-A2 | BENZOIC AND PHENYL ACETIC ACID DERIVATIVES AS HNF-4 MODULATORS | LIGAND PHARMACUETICALS INCORPORATED (US) | 2005-02-03 | — | — | WO | claimed |
| WO-2005009104-A2 | BENZOIC AND PHENYL ACETIC ACID DERIVATIVES AS HNF-4 MODULATORS | LIGAND PHARMACUETICALS INCORPORATED (US) | 2005-02-03 | — | — | WO | disclosed |