Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRM2 | P08172 | 3/20 | 0.47 |
| ▸ | HTR1A | P08908 | 2/20 | 0.47 |
| ▸ | ADRA1D | P25100 | 2/20 | 0.47 |
| ▸ | ADRA1A | P35348 | 2/20 | 0.47 |
| ▸ | ADRA1B | P35368 | 2/20 | 0.47 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.46 |
| ▸ | DRD2 | P14416 | 5/20 | 0.41 |
| ▸ | DRD4 | P21917 | 5/20 | 0.41 |
| ▸ | SCN8A | Q9UQD0 | 2/20 | 0.40 |
| ▸ | CARM1 | Q86X55 | 1/20 | 0.40 |
| ▸ | DRD3 | P35462 | 4/20 | 0.39 |
| ▸ | HTT | P42858 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.37 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.37 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.37 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.37 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6928728 | 0.83 | TAAR1 (0.55) | CHRM2HTR1AADRA1DADRA1AADRA1B | |
| SCHEMBL6234787 | 0.81 | CHRM2 (0.57) | CHRM2HTR1AADRA1DADRA1AADRA1B | |
| SCHEMBL6244580 | 0.81 | IDO1 (0.49) | CHRM2HTR1AADRA1DADRA1AADRA1B | |
| SCHEMBL21518156 | 0.80 | HTR1B (0.46) | CHRM2HTR1AADRA1DADRA1AADRA1B | |
| SCHEMBL6237592 | 0.79 | MAOB (0.40) | CHRM2HTR1AADRA1DADRA1AADRA1B | |
| SCHEMBL10087215 | 0.76 | CHRM2 (0.54) | CHRM2HTR1AADRA1DADRA1AADRA1B | |
| SCHEMBL4919388 | 0.76 | CHRM2 (0.73) | CHRM2TAAR1SCN8AHTTCHRM3 | |
| SCHEMBL4909307 | 0.76 | CHRM2 (0.73) | CHRM2TAAR1SCN8AHTTCHRM3 | |
| SCHEMBL4908322 | 0.76 | CHRM2 (0.73) | CHRM2TAAR1SCN8AHTTCHRM3 | |
| SCHEMBL6239315 | 0.76 | TSHR (0.50) | HTR1AADRA1DADRA1AADRA1BDRD2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2005011697-A2 | SULFONAMIDE DERIVATIVES WITH ACTIVITY ON PROTEIN KINASE A AND B | ASTEX THERAPEUTICS LIMITED (GB) | 2005-02-10 | — | — | WO | disclosed |