Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 4/20 | 0.88 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.88 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.88 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.88 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.88 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.72 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.59 |
| ▸ | GAA | P10253 | 2/20 | 0.58 |
| ▸ | LMNA | P02545 | 1/20 | 0.58 |
| ▸ | NPC1 | O15118 | 2/20 | 0.52 |
| ▸ | RAB9A | P51151 | 2/20 | 0.52 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.52 |
| ▸ | EGFR | P00533 | 1/20 | 0.51 |
| ▸ | PTK2 | Q05397 | 2/20 | 0.50 |
| ▸ | TSHR | P16473 | 1/20 | 0.50 |
| ▸ | GBA1 | P04062 | 2/20 | 0.49 |
| ▸ | POLB | P06746 | 1/20 | 0.47 |
| ▸ | THRB | P10828 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6237782 | 0.91 | MAPT (0.93) | MAPTALDH1A1SMN1; SMN2KDM4EKMT2A | |
| SCHEMBL29609022 | 0.91 | MAPT (0.93) | MAPTALDH1A1SMN1; SMN2KDM4EKMT2A | |
| SCHEMBL11813903 | 0.85 | MAPT (0.83) | MAPTALDH1A1SMN1; SMN2KDM4EKMT2A | |
| SCHEMBL28736347 | 0.85 | L3MBTL1 (0.67) | MAPTALDH1A1SMN1; SMN2KDM4EKMT2A | |
| Dyrene SCHEMBL8178116 | 0.80 | TSHR (0.75) | MAPTALDH1A1SMN1; SMN2KDM4EKMT2A | |
| SCHEMBL13326002 | 0.79 | MAPT (0.71) | MAPTALDH1A1SMN1; SMN2KDM4EKMT2A | |
| SCHEMBL28176767 | 0.75 | MAPT (0.65) | MAPTALDH1A1SMN1; SMN2KDM4EKMT2A | |
| Dyrene SCHEMBL1029356 | 0.74 | MAPT (0.65) | MAPTALDH1A1SMN1; SMN2KDM4EKMT2A | |
| SCHEMBL7458726 | 0.74 | LRRK2 (1.00) | LRRK2 | |
| SCHEMBL9697643 | 0.74 | MAPT (0.66) | MAPTALDH1A1SMN1; SMN2KDM4EKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-108191774-B | Heterocyclic compound, preparation method and application thereof | 中国药科大学 | 2022-05-24 | — | — | CN | disclosed |