Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADORA3 | P0DMS8 | 2/20 | 0.56 |
| ▸ | DYRK1A | Q13627 | 2/20 | 0.44 |
| ▸ | P2RY14 | Q15391 | 1/20 | 0.42 |
| ▸ | TOP2A | P11388 | 1/20 | 0.42 |
| ▸ | GSTO1 | P78417 | 1/20 | 0.41 |
| ▸ | SNCA | P37840 | 2/20 | 0.40 |
| ▸ | KIF11 | P52732 | 2/20 | 0.40 |
| ▸ | TRPV1 | Q8NER1 | 2/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | HPGD | P15428 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.39 |
| ▸ | IDO1 | P14902 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2380377 | 0.84 | ADORA3 (0.54) | ADORA3DYRK1AKDM4EMEN1ALDH1A1 | |
| SCHEMBL1856373 | 0.83 | ADORA3 (0.59) | ADORA3DYRK1A | |
| SCHEMBL27564437 | 0.82 | KMT2A (0.44) | ADORA3KDM4EMEN1ALDH1A1MAPT | |
| SCHEMBL474679 | 0.82 | KIF11 (0.49) | ADORA3KIF11 | |
| SCHEMBL10117774 | 0.81 | ALDH1A1 (0.42) | ADORA3DYRK1AKDM4EMEN1ALDH1A1 | |
| SCHEMBL8012523 | 0.81 | XDH (0.44) | ADORA3KDM4EMEN1ALDH1A1MAPT | |
| SCHEMBL4519009 | 0.81 | ADORA3 (0.53) | ADORA3KDM4EMEN1ALDH1A1MAPT | |
| SCHEMBL1201878 | 0.81 | ADORA3 (0.55) | ADORA3KDM4EMEN1ALDH1A1MAPT | |
| SCHEMBL8012036 | 0.78 | LMNA (0.41) | ADORA3KDM4EMEN1ALDH1A1MAPT | |
| SCHEMBL6152117 | 0.78 | EGLN2 (0.45) | ADORA3DYRK1AKDM4EMEN1ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2005005382-A2 | COMPOUNDS, COMPOSITIONS AND METHODS | CYTOKINETICS, INC. (US) | 2005-01-20 | — | — | WO | disclosed |