Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC3 | O15379 | 2/20 | 0.60 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.60 |
| ▸ | HDAC2 | Q92769 | 2/20 | 0.60 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.60 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.60 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.60 |
| ▸ | HDAC11 | Q96DB2 | 1/20 | 0.60 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.60 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.60 |
| ▸ | HDAC9 | Q9UKV0 | 1/20 | 0.60 |
| ▸ | HDAC5 | Q9UQL6 | 1/20 | 0.60 |
| ▸ | TAS1R3 | Q7RTX0 | 1/20 | 0.60 |
| ▸ | TAS1R1 | Q7RTX1 | 1/20 | 0.60 |
| ▸ | BCAT1 | P54687 | 2/20 | 0.59 |
| ▸ | ADAMTS4 | O75173 | 2/20 | 0.56 |
| ▸ | ADAMTS5 | Q9UNA0 | 2/20 | 0.56 |
| ▸ | NPC1 | O15118 | 2/20 | 0.56 |
| ▸ | RAB9A | P51151 | 2/20 | 0.56 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.54 |
| ▸ | ATM | Q13315 | 1/20 | 0.54 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29827697 | 0.86 | HDAC3 (0.61) | HDAC3HDAC1HDAC2HDAC4HDAC7 | |
| SCHEMBL4916668 | 0.82 | TP53 (0.72) | HDAC3HDAC1HDAC2HDAC4HDAC7 | |
| SCHEMBL705754 | 0.82 | PIM1 (0.64) | BCAT1NPC1RAB9AKDM4EHRH4 | |
| SCHEMBL29994222 | 0.82 | KDM4E (0.66) | HDAC3HDAC1HDAC2HDAC4HDAC7 | |
| SCHEMBL2706216 | 0.82 | KDM4E (0.66) | HDAC3HDAC1HDAC2HDAC4HDAC7 | |
| SCHEMBL29526778 | 0.82 | PIM1 (0.64) | BCAT1NPC1RAB9AKDM4EHRH4 | |
| SCHEMBL3613922 | 0.82 | MAOB (0.63) | HDAC3HDAC1HDAC2HDAC4HDAC7 | |
| SCHEMBL5867026 | 0.82 | NPC1 (0.71) | BCAT1NPC1RAB9AKDM4EATM | |
| SCHEMBL24173779 | 0.81 | TSHR (0.57) | HDAC3HDAC1HDAC2HDAC4HDAC7 | |
| SCHEMBL4925354 | 0.81 | HDAC3 (0.69) | HDAC3HDAC1HDAC2HDAC4HDAC7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 12 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-116178359-B | Heterocyclic substitution-based disulfide derivative, preparation method and application thereof | 贵州大学 | 2024-09-13 | — | — | CN | disclosed |
| US-20230293487-A1 | ANTI-INFLAMMATORY COMPOSITION COMPRISING BENZOFURAN-BASED N-ACYLHYDRAZONE DERIVATIVES | KOREA RESEARCH INSTITUTE OF BIOSCIENCE AND BIOTECHNOLOGY (KR) | 2023-09-21 | — | — | US | disclosed |
| US-20230293487-A1 | ANTI-INFLAMMATORY COMPOSITION COMPRISING BENZOFURAN-BASED N-ACYLHYDRAZONE DERIVATIVES | KOREA RESEARCH INSTITUTE OF BIOSCIENCE AND BIOTECHNOLOGY (KR) | 2023-09-21 | — | — | US | disclosed |
| EP-4186503-A1 | ANTI-INFLAMMATORY COMPOSITION COMPRISING BENZOFURAN-BASED N-ACYLHYDRAZONE DERIVATIVES | Korea Research Institute of Bioscience and Biotechnology (KR) | 2023-05-31 | — | — | EP | disclosed |
| CN-116178359-A | Heterocyclic substitution-based disulfide derivative, preparation method and application thereof | 贵州大学 | 2023-05-30 | — | — | CN | disclosed |
| EP-4015516-A1 | BENZOFURAN-BASED N-ACYLHYDRAZONE DERIVATIVE AND PHARMACEUTICAL COMPOSITION COMPRISING SAME | Korea Research Institute of Bioscience and Biotechnology (KR) | 2022-06-22 | — | — | EP | disclosed |
| WO-2021251756-A1 | N-ACYLHYDRAZONE-DERIVATIVE-MARKER CONJUGATE AND PHARMACEUTICAL COMPOSITION CONTAINING SAME | 한국생명공학연구원 | 2021-12-16 | — | — | WO | disclosed |
| WO-2021010731-A1 | BENZOFURAN-BASED N-ACYLHYDRAZONE DERIVATIVE AND PHARMACEUTICAL COMPOSITION COMPRISING SAME | 한국생명공학연구원 | 2021-01-21 | — | — | WO | disclosed |
| EP-1320523-B1 | BRANCHED CHAIN AMINO ACID-DEPENDENT AMINOTRANSFERASE INHIBITORS AND THEIR USE IN THE TREATMENT OF NEURODEGENERATIVE DISEASES | WARNER LAMBERT CO (US) | 2005-06-22 | — | — | EP | disclosed |
| US-20050004167-A1 | Branched chain amino acid-dependent aminotransferase inhibitors and their use in the treatment of neurodegenerative diseases | WARNER-LAMBERT COMPANY LLC | 2005-01-06 | — | — | US | disclosed |
| EP-1320523-A2 | BRANCHED CHAIN AMINO ACID-DEPENDENT AMINOTRANSFERASE INHIBITORS AND THEIR USE IN THE TREATMENT OF NEURODEGENERATIVE DISEASES | Warner-Lambert Company LLC (US) | 2003-06-25 | — | — | EP | disclosed |
| WO-2002024672-A2 | BRANCHED CHAIN AMINO ACID-DEPENDENT AMINOTRANSFERASE INHIBITORS AND THEIR USE IN THE TREATMENT OF NEURODEGENERATIVE DISEASES | WARNER-LAMBERT COMPANY LLC (US) | 2002-03-28 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050004167-A1 | Branched chain amino acid-dependent aminotransferase inhibitors and their use in the treatment of neurodegenerative diseases | BCAT1, BCAT2, ABAT | HDAC3 2570/4885HDAC1 2750/4885HDAC2 2545/4885 |
| US-20230293487-A1 | ANTI-INFLAMMATORY COMPOSITION COMPRISING BENZOFURAN-BASED N-ACYLHYDRAZONE DERIVATIVES | RELA, NFKBIA, IKBKG | HDAC3 55/4885HDAC1 84/4885HDAC2 91/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.