Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIM1 | P11309 | 7/20 | 0.44 |
| ▸ | TYRO3 | Q06418 | 1/20 | 0.42 |
| ▸ | F2RL3 | Q96RI0 | 6/20 | 0.41 |
| ▸ | PIM3 | Q86V86 | 3/20 | 0.39 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.38 |
| ▸ | FGFR2 | P21802 | 1/20 | 0.38 |
| ▸ | KDR | P35968 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 2/20 | 0.38 |
| ▸ | FLT3 | P36888 | 2/20 | 0.37 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.37 |
| ▸ | PIM2 | Q9P1W9 | 2/20 | 0.37 |
| ▸ | TP53 | P04637 | 1/20 | 0.37 |
| ▸ | GAA | P10253 | 1/20 | 0.37 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.37 |
| ▸ | FYN | P06241 | 1/20 | 0.37 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.37 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.37 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.37 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.37 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL625331 | 0.84 | PIM1 (0.45) | PIM1F2RL3MAPTKCNH2PIM2 | |
| SCHEMBL624904 | 0.84 | F2RL3 (0.41) | PIM1F2RL3PIM3FGFR1FGFR2 | |
| SCHEMBL624008 | 0.83 | PIM1 (0.56) | PIM1PIM3FLT3KCNH2PIM2 | |
| SCHEMBL625504 | 0.81 | PIM1 (0.56) | PIM1TYRO3F2RL3PIM3FLT3 | |
| Hydrochloric Acid SCHEMBL625023 | 0.77 | PIM1 (0.45) | PIM1TYRO3F2RL3PIM3FLT3 | |
| SCHEMBL623014 | 0.77 | F2RL3 (0.42) | PIM1F2RL3PIM3MAPTFLT3 | |
| SCHEMBL623580 | 0.74 | PIM1 (0.40) | PIM1TYRO3PIM3MAPTFLT3 | |
| SCHEMBL1945253 | 0.74 | PIM1 (0.47) | PIM1F2RL3PIM3FLT3KCNH2 | |
| SCHEMBL624816 | 0.73 | PIM1 (0.51) | PIM1TYRO3F2RL3PIM3FLT3 | |
| SCHEMBL623807 | 0.73 | ALDH1A1 (0.40) | PIM1TYRO3F2RL3FGFR1KDR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012020217-A1 | AMINO- IMIDAZOLOTHIADIAZOLES FOR USE AS PROTEIN OR LIPID KINASE INHIBITORS | CENTRO NACIONAL DE INVESTIGACIONES ONCOLÓGICAS (CNIO) (ES) | 2012-02-16 | — | — | WO | disclosed |