Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIM1 | P11309 | 5/20 | 0.45 |
| ▸ | GPR119 | Q8TDV5 | 3/20 | 0.40 |
| ▸ | GLS | O94925 | 1/20 | 0.40 |
| ▸ | ABHD6 | Q9BV23 | 1/20 | 0.38 |
| ▸ | DAGLA | Q9Y4D2 | 1/20 | 0.38 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.37 |
| ▸ | PIM2 | Q9P1W9 | 1/20 | 0.37 |
| ▸ | HPGD | P15428 | 3/20 | 0.37 |
| ▸ | MAPT | P10636 | 2/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.37 |
| ▸ | SCN5A | Q14524 | 1/20 | 0.37 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.37 |
| ▸ | F2RL3 | Q96RI0 | 1/20 | 0.37 |
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
| ▸ | USP2 | O75604 | 1/20 | 0.37 |
| ▸ | GAA | P10253 | 1/20 | 0.37 |
| ▸ | TSHR | P16473 | 1/20 | 0.37 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL624434 | 0.88 | JAK2 (0.48) | GPR119HPGDMAPTKDM4EALDH1A1 | |
| SCHEMBL624009 | 0.84 | PIM1 (0.44) | PIM1KCNH2PIM2MAPTF2RL3 | |
| SCHEMBL625330 | 0.84 | PIM1 (0.52) | PIM1KCNH2PIM2 | |
| SCHEMBL624533 | 0.84 | PIM1 (0.53) | PIM1GLSKCNH2PIM2MAPT | |
| SCHEMBL623580 | 0.82 | PIM1 (0.40) | PIM1GLSKCNH2PIM2MAPT | |
| SCHEMBL623873 | 0.82 | IDH1 (0.44) | PIM1GPR119ABHD6DAGLAKCNH2 | |
| SCHEMBL627188 | 0.78 | GPR119 (0.40) | GPR119GLSHPGDMAPTKDM4E | |
| SCHEMBL625512 | 0.77 | THRB (0.44) | PIM1MAPTF2RL3GAA | |
| SCHEMBL624454 | 0.77 | PIM1 (0.45) | PIM1GPR119ABHD6DAGLAKCNH2 | |
| SCHEMBL623029 | 0.77 | ACKR3 (0.51) | PIM1ABHD6DAGLAF2RL3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012020217-A1 | AMINO- IMIDAZOLOTHIADIAZOLES FOR USE AS PROTEIN OR LIPID KINASE INHIBITORS | CENTRO NACIONAL DE INVESTIGACIONES ONCOLÓGICAS (CNIO) (ES) | 2012-02-16 | — | — | WO | disclosed |