Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | POLB | P06746 | 1/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.40 |
| ▸ | NR5A2 | O00482 | 1/20 | 0.39 |
| ▸ | NPC1 | O15118 | 1/20 | 0.39 |
| ▸ | RAB9A | P51151 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
| ▸ | F2RL3 | Q96RI0 | 3/20 | 0.39 |
| ▸ | MAP4K4 | O95819 | 2/20 | 0.38 |
| ▸ | AURKA | O14965 | 1/20 | 0.38 |
| ▸ | DAPK3 | O43293 | 1/20 | 0.38 |
| ▸ | JAK2 | O60674 | 1/20 | 0.38 |
| ▸ | ABL1 | P00519 | 1/20 | 0.38 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.38 |
| ▸ | CSF1R | P07333 | 1/20 | 0.38 |
| ▸ | RET | P07949 | 1/20 | 0.38 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.38 |
| ▸ | PRKACA | P17612 | 1/20 | 0.38 |
| ▸ | KDR | P35968 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL625257 | 0.81 | FYN (0.47) | NR5A2NPC1RAB9ASMN1; SMN2MAP4K4 | |
| SCHEMBL623806 | 0.81 | FYN (0.54) | PIM1PIM2FYN | |
| SCHEMBL624434 | 0.77 | JAK2 (0.48) | ALDH1A1L3MBTL1SMN1; SMN2F2RL3JAK2 | |
| SCHEMBL624904 | 0.77 | F2RL3 (0.41) | NPC1RAB9ASMN1; SMN2F2RL3JAK2 | |
| SCHEMBL625331 | 0.75 | PIM1 (0.45) | ALDH1A1L3MBTL1F2RL3JAK2PIM1 | |
| SCHEMBL2250766 | 0.74 | FYN (0.53) | NPC1RAB9ASMN1; SMN2F2RL3PIM1 | |
| SCHEMBL624009 | 0.73 | PIM1 (0.44) | F2RL3FGFR1KDRTYRO3PIM1 | |
| SCHEMBL1945954 | 0.70 | FYN (0.56) | NR5A2PIM1PIM2FYN | |
| SCHEMBL1946233 | 0.70 | FYN (0.56) | ALDH1A1LMNANPC1FYNHRH3 | |
| SCHEMBL15603196 | 0.70 | FYN (0.66) | NPC1RAB9ASMN1; SMN2F2RL3MAP4K4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012020217-A1 | AMINO- IMIDAZOLOTHIADIAZOLES FOR USE AS PROTEIN OR LIPID KINASE INHIBITORS | CENTRO NACIONAL DE INVESTIGACIONES ONCOLÓGICAS (CNIO) (ES) | 2012-02-16 | — | — | WO | disclosed |