Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 19/20 | 0.55 |
| ▸ | THRB | P10828 | 4/20 | 0.54 |
| ▸ | LMNA | P02545 | 6/20 | 0.52 |
| ▸ | TP53 | P04637 | 3/20 | 0.52 |
| ▸ | POLB | P06746 | 3/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL625777 | 0.89 | MAPT (0.56) | MAPTTHRBLMNATP53POLB | |
| SCHEMBL623998 | 0.85 | PIM1 (0.51) | MAPTTP53 | |
| SCHEMBL624450 | 0.83 | PIM1 (0.54) | MAPTTHRBLMNATP53POLB | |
| SCHEMBL624017 | 0.80 | MAPT (0.49) | MAPTTHRBLMNATP53POLB | |
| SCHEMBL624634 | 0.80 | MAPT (0.52) | MAPTTHRBLMNATP53POLB | |
| SCHEMBL628100 | 0.77 | MAPT (0.54) | MAPTTHRBLMNATP53POLB | |
| SCHEMBL623867 | 0.75 | PIM1 (0.44) | MAPTTHRB | |
| SCHEMBL625035 | 0.75 | THRB (0.48) | MAPTTHRB | |
| SCHEMBL625742 | 0.75 | THRB (0.43) | MAPTTHRBPOLB | |
| SCHEMBL625776 | 0.73 | PIM1 (0.55) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012020217-A1 | AMINO- IMIDAZOLOTHIADIAZOLES FOR USE AS PROTEIN OR LIPID KINASE INHIBITORS | CENTRO NACIONAL DE INVESTIGACIONES ONCOLÓGICAS (CNIO) (ES) | 2012-02-16 | — | — | WO | disclosed |