Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIM1 | P11309 | 9/20 | 0.47 |
| ▸ | FYN | P06241 | 7/20 | 0.45 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.41 |
| ▸ | DYRK1A | Q13627 | 3/20 | 0.40 |
| ▸ | DYRK2 | Q92630 | 3/20 | 0.40 |
| ▸ | CCNA2 | P20248 | 2/20 | 0.40 |
| ▸ | CDK2 | P24941 | 2/20 | 0.40 |
| ▸ | CDK5 | Q00535 | 2/20 | 0.40 |
| ▸ | CDK5R1 | Q15078 | 2/20 | 0.40 |
| ▸ | DYRK1B | Q9Y463 | 2/20 | 0.40 |
| ▸ | CCNT1 | O60563 | 1/20 | 0.40 |
| ▸ | CDK9 | P50750 | 1/20 | 0.40 |
| ▸ | MKNK1 | Q9BUB5 | 1/20 | 0.40 |
| ▸ | AURKA | O14965 | 1/20 | 0.39 |
| ▸ | FLT3 | P36888 | 1/20 | 0.39 |
| ▸ | GSK3B | P49841 | 1/20 | 0.39 |
| ▸ | PIM3 | Q86V86 | 1/20 | 0.39 |
| ▸ | PIM2 | Q9P1W9 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL623848 | 0.90 | DYRK1A (0.47) | PIM1FYNKCNH2DYRK1ADYRK2 | |
| SCHEMBL623881 | 0.82 | FYN (0.60) | PIM1FYNKCNH2MKNK1PIM3 | |
| SCHEMBL17004609 | 0.80 | FYN (0.67) | PIM1FYNKCNH2DYRK1ADYRK2 | |
| SCHEMBL624880 | 0.78 | PIM1 (0.51) | PIM1KCNH2DYRK1A | |
| SCHEMBL1946065 | 0.74 | FYN (0.68) | PIM1FYNKCNH2MKNK1PIM2 | |
| SCHEMBL1945221 | 0.74 | FYN (0.76) | PIM1FYNKCNH2DYRK1ADYRK2 | |
| SCHEMBL27815771 | 0.74 | DYRK1A (0.53) | PIM1FYNKCNH2DYRK1ADYRK2 | |
| SCHEMBL624030 | 0.74 | FYN (0.59) | PIM1FYNKCNH2MKNK1PIM3 | |
| SCHEMBL625548 | 0.73 | FYN (0.52) | PIM1FYNKCNH2DYRK1ADYRK2 | |
| SCHEMBL623882 | 0.73 | DYRK1A (0.46) | PIM1FYNKCNH2DYRK1ADYRK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012020217-A1 | AMINO- IMIDAZOLOTHIADIAZOLES FOR USE AS PROTEIN OR LIPID KINASE INHIBITORS | CENTRO NACIONAL DE INVESTIGACIONES ONCOLÓGICAS (CNIO) (ES) | 2012-02-16 | — | — | WO | disclosed |