SCHEMBL624628

SCHEMBL624628

Nc1ccn([C@@H]2O[C@H](COP(=O)(O)OP(=O)(O)OP(=O)(O)O)[C@@H](O)[C@H]2O)c(=S)n1

nearest known ligand 0.75

Predicted protein targets (top 3)

geneUniProtsupporting neighboursconfidence
P2RY2 P41231 20/20 0.75
P2RY4 P51582 10/20 0.75
P2RY6 Q15077 6/20 0.62

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL21418843 1.00 P2RY2 (0.75) P2RY2P2RY4P2RY6
SCHEMBL21418842 1.00 P2RY2 (0.75) P2RY2P2RY4P2RY6
SCHEMBL17972336 1.00 P2RY2 (0.75) P2RY2P2RY4P2RY6
SCHEMBL3502990 1.00 P2RY2 (0.75) P2RY2P2RY4P2RY6
SCHEMBL15810740 1.00 P2RY2 (0.75) P2RY2P2RY4P2RY6
SCHEMBL24371631 0.92 P2RY2 (0.66) P2RY2P2RY4P2RY6
SCHEMBL21418572 0.92 P2RY2 (0.64) P2RY2P2RY4P2RY6
SCHEMBL24371531 0.92 P2RY2 (0.66) P2RY2P2RY4P2RY6
SCHEMBL24372005 0.92 P2RY2 (0.66) P2RY2P2RY4P2RY6
SCHEMBL16575673 0.92 P2RY2 (0.66) P2RY2P2RY4P2RY6

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1400 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-12460204-B2 Artificial nucleic acid molecules for improved protein or peptide expression CureVac SE (DE) 2025-11-04 US claimed
US-20250136711-A1 SEMENOGELIN NEUTRALIZING ANTIBODY AND EPITOPE AND APPLICATION THEREOF SHANGHAI BIOTROY BIOTECHNIQUE CO., LTD (CN) 2025-05-01 US claimed
US-20240415958-A1 MESSENGER RNA THERAPY FOR TREATMENT OF ARTICULAR DISEASE TRANSLATE BIO INC (US) 2024-12-19 US claimed
CN-118924887-A HPV MRNA LNP vaccine 南京吉迈生物技术有限公司 2024-11-12 CN claimed
US-11998601-B2 Messenger RNA therapy for treatment of articular disease TRANSLATE BIO, INC. (US) 2024-06-04 US claimed
US-11980672-B2 Heterologous UTR sequences for enhanced mRNA expression MODERNATX, INC. (US) 2024-05-14 US claimed
US-11951120-B2 Modification of gene transcription and translation efficiency by 5′UTR sequence variation Nanjing GeneLeap Biotechnology Co., Ltd. 2024-04-09 US claimed
US-20230310484-A1 Modification of Gene Transcription and Translation Efficiency by 5'UTR Sequence Variation Nanjing GeneLeap Biotechnology Co., Ltd. (CN) 2023-10-05 US claimed
CN-116179549-A Modification of gene transcription and translation efficiency by 5' UTR sequence variants 南京吉迈生物技术有限公司 2023-05-30 CN claimed
US-20230050143-A1 Heterologous UTR Sequences for Enhanced mRNA Expression MODERNATX, INC. (US) 2023-02-16 US claimed
US-20100047261-A1 BASE-MODIFIED RNA FOR INCREASING THE EXPRESSION OF A PROTEIN CUREVAC GMBH (DE) 2010-02-25 US claimed
EP-2083851-A2 (BASE-)MODIFIED RNA FOR INCREASING THE EXPRESSION OF A PROTEIN Curevac GmbH (DE) 2009-08-05 EP claimed
WO-2008052770-A2 (BASE-)MODIFIED RNA FOR INCREASING THE EXPRESSION OF A PROTEIN CUREVAC GMBH (DE) 2008-05-08 WO claimed
EP-1624059-A2 Method of producing nucleic acid molecules with reduced secondary structure Agilent Technologies, Inc. (US) 2006-02-08 EP claimed
US-20040086880-A1 Method of producing nucleic acid molecules with reduced secondary structure AGILENT TECHNOLOGIES, INC. 2004-05-06 US claimed
US-20030039976-A1 Methods for base counting PE CORPORATION (NY) 2003-02-27 US claimed
EP-1261339-A1 USE OF N-SUBSTITUTED-1,5-DIDEOXY-1,5-IMINO-D-GLUCITOL COMPOUNDS FOR TREATING HEPATITIS VIRUS INFECTIONS Pharmacia Corporation (US) 2002-12-04 EP claimed
WO-2001060366-A1 USE OF N-SUBSTITUTED-1,5-DIDEOXY-1,5-IMINO-D-GLUCITOL COMPOUNDS FOR TREATING HEPATITIS VIRUS INFECTIONS PHARMACIA CORPORATION (US) 2001-08-23 WO claimed
EP-1007058-A1 USE OF $i(N)-SUBSTITUTED-1,5-DIDEOXY-1,5-IMINO-D-GLUCITOL COMPOUNDS IN COMBINATION THERAPY FOR TREATING HEPATITIS VIRUS INFECTIONS G.D. Searle & Co. (US) 2000-06-14 EP claimed
WO-1998035685-A1 USE OF N-SUBSTITUTED-1,5-DIDEOXY-1,5-IMINO-D-GLUCITOL COMPOUNDS IN COMBINATION THERAPY FOR TREATING HEPATITIS VIRUS INFECTIONS G.D. SEARLE AND CO. (US) 1998-08-20 WO claimed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (6 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20230050143-A1 Heterologous UTR Sequences for Enhanced mRNA Expression RNGTT, UPF1, RNMT P2RY2 4412/4885P2RY4 4672/4885P2RY6 4640/4885
US-12460204-B2 Artificial nucleic acid molecules for improved protein or peptide expression RNMT, NSUN3, RNGTT P2RY2 2992/4885P2RY4 2730/4885P2RY6 2967/4885
US-20100047261-A1 BASE-MODIFIED RNA FOR INCREASING THE EXPRESSION OF A PROTEIN RNMT, RNASE1, NSUN3 P2RY2 4516/4885P2RY4 4740/4885P2RY6 4642/4885
US-11980672-B2 Heterologous UTR sequences for enhanced mRNA expression RNGTT, UPF1, RNMT P2RY2 4412/4885P2RY4 4672/4885P2RY6 4640/4885
US-20240415958-A1 MESSENGER RNA THERAPY FOR TREATMENT OF ARTICULAR DISEASE NSUN3, RNMT, TRDMT1 P2RY2 3741/4885P2RY4 4107/4885P2RY6 3298/4885
US-11998601-B2 Messenger RNA therapy for treatment of articular disease NSUN3, RNMT, TRDMT1 P2RY2 3741/4885P2RY4 4107/4885P2RY6 3298/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.