Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRK2 | P25098 | 1/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.39 |
| ▸ | RECQL | P46063 | 1/20 | 0.39 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.37 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.37 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.37 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.37 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.37 |
| ▸ | RORC | P51449 | 1/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | P4HB | P07237 | 1/20 | 0.36 |
| ▸ | BRAF | P15056 | 1/20 | 0.36 |
| ▸ | KDR | P35968 | 1/20 | 0.36 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.36 |
| ▸ | TNNI3K | Q59H18 | 1/20 | 0.36 |
| ▸ | CFTR | P13569 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6247880 | 0.89 | RECQL (0.43) | RECQLKMT2AP4HBALDH1A1LMNA | |
| SCHEMBL6248753 | 0.83 | EPHX1 (0.37) | RECQLALDH1A1LMNAMAPT | |
| SCHEMBL6246353 | 0.83 | RORC (0.40) | RECQLCYP3A4CYP2C9RORCVNN1 | |
| SCHEMBL6246207 | 0.82 | LMNA (0.34) | RECQLKMT2AALDH1A1LMNA | |
| SCHEMBL6248097 | 0.81 | PTGS1 (0.44) | L3MBTL1RECQLCYP1A2CYP3A4CYP2D6 | |
| SCHEMBL6247079 | 0.81 | JAK2 (0.38) | RECQLRORCALDH1A1LMNAMAPT | |
| SCHEMBL6265380 | 0.81 | LMNA (0.41) | KMT2AKDM4EALDH1A1LMNAMAPT | |
| SCHEMBL6246114 | 0.81 | ALDH1A1 (0.48) | L3MBTL1KMT2AALDH1A1LMNAMAPT | |
| SCHEMBL6246126 | 0.80 | RECQL (0.34) | RECQLALDH1A1LMNAMAPTPKM | |
| SCHEMBL6244821 | 0.79 | NQO2 (0.46) | CYP1A2CYP3A4CYP2D6CYP2C9CYP2C19 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2005037196-A2 | SUBSTITUTED 2-ARYLMETHYLENE-N-ARYL-N'-ARYL-MALONAMIDES AND ANALOGS AS ACTIVATORS OF CASPASES AND INDUCERS OF APOPTOSIS | CYTOVIA, INC. (US) | 2005-04-28 | — | — | WO | claimed |