Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 8/20 | 0.41 |
| ▸ | MAPT | P10636 | 5/20 | 0.41 |
| ▸ | HPGD | P15428 | 3/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.38 |
| ▸ | TP53 | P04637 | 1/20 | 0.38 |
| ▸ | POLB | P06746 | 2/20 | 0.38 |
| ▸ | HTT | P42858 | 3/20 | 0.36 |
| ▸ | NPC1 | O15118 | 1/20 | 0.36 |
| ▸ | RAB9A | P51151 | 1/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | GAA | P10253 | 1/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | TSHR | P16473 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6247880 | 0.84 | RECQL (0.43) | LMNAMAPTHPGDALDH1A1SMN1; SMN2 | |
| SCHEMBL6246748 | 0.81 | GRK2 (0.40) | LMNAMAPTALDH1A1HTTKDM4E | |
| SCHEMBL6248753 | 0.80 | EPHX1 (0.37) | LMNAMAPTALDH1A1 | |
| SCHEMBL6246353 | 0.80 | RORC (0.40) | — | |
| SCHEMBL6246114 | 0.78 | ALDH1A1 (0.48) | LMNAMAPTHPGDALDH1A1POLB | |
| SCHEMBL6248564 | 0.76 | MAPT (0.43) | MAPTTP53POLB | |
| SCHEMBL6248097 | 0.76 | PTGS1 (0.44) | LMNAMAPTSMN1; SMN2POLBHTT | |
| SCHEMBL6248665 | 0.76 | EPHX2 (0.47) | LMNAMAPTHPGDALDH1A1HTT | |
| SCHEMBL6246207 | 0.75 | LMNA (0.34) | LMNAALDH1A1GAAMEN1KMT2A | |
| SCHEMBL5142394 | 0.74 | RAB9A (0.58) | LMNAMAPTALDH1A1SMN1; SMN2POLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2005037196-A2 | SUBSTITUTED 2-ARYLMETHYLENE-N-ARYL-N'-ARYL-MALONAMIDES AND ANALOGS AS ACTIVATORS OF CASPASES AND INDUCERS OF APOPTOSIS | CYTOVIA, INC. (US) | 2005-04-28 | — | — | WO | claimed |