Known targets — ChEMBL curated mechanism
ABCC9ABL1ACEACHEACVR1ADORA1ADORA2AADORA2BADORA3ADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2ADRB3AGTR1ALOX5ATP4AATP4BBCRBTKCACNA1ACACNA1BCACNA1CCACNA1DCACNA1ECACNA1FCACNA1GCACNA1HCACNA1ICACNA1SCACNA2D1CACNA2D2CACNA2D3CACNA2D4CACNB1CACNB2CACNB3CACNB4CACNG1CACNG2CACNG3CACNG4CACNG5CACNG6CACNG7CACNG8CALCRLCFBCHRM1CHRM2CHRM3CHRM4CHRM5CHRNA1CHRNB1CHRNDCHRNECHRNGCRBNCUL4ACXCR1CXCR2DDB1DDCDHFRDPP4DRD2DRD3DRD4EGFRERBB2ERBB4ESR1ESR2FDPSFKBP1AFLT1FLT3FLT4GARTGHSRGRIA1GRIA2GRIA3GRIA4GRIK1GRIK2GRIK3GRIK4GRIK5GRIN2AGSK3AGSK3BHDAC1HDAC10HDAC11HDAC2HDAC3HDAC4HDAC5HDAC6HDAC7HDAC8HDAC9HRH1HTR1AHTR1BHTR1DHTR1EHTR1FHTR2AHTR2BHTR2CHTR3AHTR3BHTR3CHTR3DHTR3EHTR4HTR5AHTR6HTR7IDH1IDH2IMPA1ITGA2BITGB3JAK1JAK2JAK3KCNJ11KCNK3KCNK9KDRKITMEN1METMMP1MMP13MMP7MMP8NANOD2NS5bODC1OPG057OPRD1OPRK1OPRM1PPARP1PARP2PDE3APDE3BPDE4APDE4BPDE4CPDE4DPDGFRBPIK3CAPIK3CBPIK3CDPIK3CGPIK3R1PIK3R2PIK3R3PIK3R5PKLRPPARDPPATPTGS1PTGS2RBX1ROCK1ROCK2RRM1RRM2RRM2BSCN10ASCN11ASCN1ASCN2ASCN3ASCN4ASCN5ASCN7ASCN8ASCN9ASCNN1ASCNN1BSCNN1GSIGMAR1SLC10A2SLC5A2SLC6A2SLC6A3SLC6A4SLC9A3SYKTACR1THRATHRBTOP1TUBA1ATUBA1BTUBA1CTUBA3CTUBA3ETUBA4ATUBBTUBB1TUBB2ATUBB2BTUBB3TUBB4ATUBB4BTUBB6TUBB8TYK2TYMSVDRampCblablaT-3blaT-4blaT-5blaT-6blaUOE-1dacAdacBdacCfolAfolPftsIgyrAgyrBileSmecAmrcAmrcBmrdAparCparEpbp2pbp4pbpApbpFrplArplBrplCrplDrplErplFrplIrplJrplKrplLrplMrplNrplOrplPrplQrplRrplSrplTrplUrplVrplWrplXrplYrpmArpmBrpmCrpmDrpmErpmE2rpmFrpmGrpmG1rpmG2rpmG3rpmHrpmIrpmJrpsArpsBrpsCrpsDrpsErpsFrpsGrpsHrpsIrpsJrpsKrpsLrpsMrpsNrpsOrpsPrpsQrpsRrpsSrpsTrpsUthyAykgMykgO
The experimentally established mechanism targets of Butyric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC3 known ✓ | O15379 | 1/20 | 0.59 |
| ▸ | HDAC1 known ✓ | Q13547 | 1/20 | 0.59 |
| ▸ | HDAC2 known ✓ | Q92769 | 1/20 | 0.59 |
| ▸ | HDAC8 known ✓ | Q9BY41 | 1/20 | 0.59 |
| ▸ | PPARD known ✓ | Q03181 | 7/20 | 0.39 |
| ▸ | HDAC11 known ✓ | Q96DB2 | 5/20 | 0.39 |
| ▸ | MEN1 known ✓ | O00255 | 1/20 | 0.39 |
| ▸ | ESR1 known ✓ | P03372 | 1/20 | 0.39 |
| ▸ | PDE4A known ✓ | P27815 | 1/20 | 0.39 |
| ▸ | PDE3A known ✓ | Q14432 | 1/20 | 0.39 |
| ▸ | FFAR3 | O14843 | 1/20 | 0.59 |
| ▸ | TSHR | P16473 | 5/20 | 0.41 |
| ▸ | TDP1 | Q9NUW8 | 3/20 | 0.41 |
| ▸ | NAPRT | Q6XQN6 | 1/20 | 0.41 |
| ▸ | AKR1B1 | P15121 | 1/20 | 0.41 |
| ▸ | GPR84 | Q9NQS5 | 7/20 | 0.39 |
| ▸ | PPARG | P37231 | 7/20 | 0.39 |
| ▸ | PPARA | Q07869 | 7/20 | 0.39 |
| ▸ | PTPN1 | P18031 | 3/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Butyric Acid SCHEMBL5874604 | 0.98 | FFAR3 (0.62) | FFAR3HDAC3HDAC1HDAC2HDAC8 | |
| Butyric Acid SCHEMBL5456396 | 0.98 | FFAR3 (0.62) | FFAR3HDAC3HDAC1HDAC2HDAC8 | |
| Butyric Acid SCHEMBL28654166 | 0.95 | FFAR3 (0.59) | FFAR3HDAC3HDAC1HDAC2HDAC8 | |
| Butyric Acid SCHEMBL28046716 | 0.95 | FFAR3 (0.59) | FFAR3HDAC3HDAC1HDAC2HDAC8 | |
| Butyric Acid SCHEMBL27333060 | 0.95 | FFAR3 (0.59) | FFAR3HDAC3HDAC1HDAC2HDAC8 | |
| Butyric Acid SCHEMBL28228470 | 0.95 | FFAR3 (0.59) | FFAR3HDAC3HDAC1HDAC2HDAC8 | |
| Cyclohexane SCHEMBL11750527 | 0.91 | FFAR3 (0.54) | FFAR3HDAC3HDAC1HDAC2HDAC8 | |
| Butyric Acid SCHEMBL1649007 | 0.88 | FFAR3 (0.68) | FFAR3HDAC3HDAC1HDAC2HDAC8 | |
| Butyric Acid SCHEMBL11484161 | 0.85 | FFAR3 (0.81) | FFAR3HDAC3HDAC1HDAC2HDAC8 | |
| Valeric Acid SCHEMBL5875456 | 0.84 | AKR1B1 (0.56) | TSHRTDP1AKR1B1GPR84PPARG |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 17 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2005039381-A2 | COMPOSITIONS AND PROCESSES FOR ANALYSIS OF PHARMACOLOGIC AGENTS IN BIOLOGICAL SAMPLES | DRUG RISK SOLUTIONS, L.L.C. (US) | 2005-05-06 | — | — | WO | disclosed |
| US-20050037386-A1 | Composition and processes for analysis of pharmacologic agents in biological samples | DRUG RISK SOLUTIONS, L.L.C. | 2005-02-17 | — | — | US | disclosed |
| US-20030215529-A1 | Composition and pharmaceutical preparation containing same for the treatment of herpes and related viral infections | DALHOUSIE UNIVERSITY | 2003-11-20 | — | — | US | disclosed |
| US-5843890-A | Antibiotic GE 2270 factors B1, B2, C1, C2, D1, D2, E and T | GRUPPO LEPETIT S.P.A. (IT) | 1998-12-01 | — | — | US | disclosed |
| US-5747295-A | Antibiotic GE 2270 factors B1, B2, C1, C2, D1, D2, E and T | GRUPPO LEPETIT S.P.A. (IT) | 1998-05-05 | — | — | US | disclosed |
| EP-0451486-B1 | Antibiotic GE 2270 factors B1, B2, C1, C2, D1, D2,E and T | LEPETIT SPA (IT) | 1995-04-19 | — | — | EP | disclosed |
| US-5322777-A | Administering for bacterial infections; obtained from culture of Planobispora rosea ATCC 53773 | GRUPPO LEPETIT S.P.A. (IT) | 1994-06-21 | — | — | US | disclosed |
| EP-0359062-B1 | Antibiotic GE 2270 | LEPETIT SPA (IT) | 1994-02-16 | — | — | EP | disclosed |
| US-5202241-A | Spectrum analysis of physiochemical and biological properties; useful in treatment of infection diseases involving microorganism susceptible to them; culture product | GRUPPO LEPETIT S.P.A. (IT) | 1993-04-13 | — | — | US | disclosed |
| EP-0240609-B1 | ANTIBIOTIC A 40926 N-ACYLAMINOGLUCURONYL AGLYCONS AND ANTIBIOTIC A 40926 AGLYCON | GRUPPO LEPETIT S.p.A. (IT) | 1991-12-04 | — | — | EP | disclosed |
| EP-0451486-A1 | Antibiotic GE 2270 factors B1, B2, C1, C2, D1, D2,E and T | GRUPPO LEPETIT S.p.A. (IT) | 1991-10-16 | — | — | EP | disclosed |
| US-4935238-A | Glycopeptidic substance; vancomycin class of antibiotics | GRUPPO LEPETIT, S.P.A. (IT) | 1990-06-19 | — | — | US | disclosed |
| EP-0359062-A2 | Antibiotic GE 2270 | GRUPPO LEPETIT S.p.A. (IT) | 1990-03-21 | — | — | EP | disclosed |
| EP-0177882-B1 | ANTIBIOTIC A 40926 COMPLEX AND ITS PURE FACTORS PA, PB, A, B AND BO | GRUPPO LEPETIT S.p.A. (IT) | 1990-01-03 | — | — | EP | disclosed |
| US-4868171-A | Antibiotic A 40926 N-acylaminoglucuronyl aglycons and antiobiotic A 40926 aglycon | GRUPPO LEPETIT S.P.A. (IT) | 1989-09-19 | — | — | US | disclosed |
| EP-0240609-A2 | Antibiotic A 40926 N-acylaminoglucuronyl aglycons and antibiotic A 40926 aglycon | GRUPPO LEPETIT S.p.A. (IT) | 1987-10-14 | — | — | EP | disclosed |
| EP-0177882-A2 | Antibiotic A 40926 complex and its pure factors PA, PB, A, B and BO | GRUPPO LEPETIT S.p.A. (IT) | 1986-04-16 | — | — | EP | disclosed |