Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 1/20 | 0.50 |
| ▸ | AKT1 | P31749 | 1/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.47 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.47 |
| ▸ | MMP2 | P08253 | 1/20 | 0.46 |
| ▸ | MMP9 | P14780 | 1/20 | 0.46 |
| ▸ | MMP8 | P22894 | 1/20 | 0.46 |
| ▸ | AAK1 | Q2M2I8 | 1/20 | 0.46 |
| ▸ | GPR142 | Q7Z601 | 6/20 | 0.45 |
| ▸ | CSK | P41240 | 1/20 | 0.44 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6248350 | 1.00 | TSHR (0.50) | TSHRAKT1ALDH1A1CYP3A4MMP2 | |
| Hydrochloric Acid SCHEMBL7894482 | 0.98 | TSHR (0.49) | TSHRAKT1ALDH1A1CYP3A4MMP2 | |
| SCHEMBL14090290 | 0.83 | ALDH1A1 (0.45) | TSHRAKT1ALDH1A1CYP3A4GPR142 | |
| SCHEMBL989802 | 0.82 | SLC7A5 (0.63) | MMP2 | |
| SCHEMBL7648961 | 0.82 | SLC7A5 (0.63) | MMP2 | |
| SCHEMBL583592 | 0.82 | SLC7A5 (0.63) | MMP2 | |
| SCHEMBL12992547 | 0.82 | HSD17B10 (0.47) | TSHRAKT1ALDH1A1CYP3A4AAK1 | |
| SCHEMBL14338226 | 0.82 | HSD17B10 (0.47) | TSHRAKT1ALDH1A1CYP3A4AAK1 | |
| SCHEMBL14317338 | 0.82 | HSD17B10 (0.47) | TSHRAKT1ALDH1A1CYP3A4AAK1 | |
| SCHEMBL7035589 | 0.82 | GPR142 (0.57) | TSHRAKT1AAK1GPR142 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2005040095-A1 | INHIBITORS OF DIPEPTIDYL PEPTIDASE IV | ASTRAZENECA AB (SE) | 2005-05-06 | — | — | WO | disclosed |