Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FYN | P06241 | 14/20 | 0.53 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.38 |
| ▸ | GRIN1 | Q05586 | 1/20 | 0.38 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.38 |
| ▸ | JAK2 | O60674 | 1/20 | 0.37 |
| ▸ | JAK3 | P52333 | 1/20 | 0.37 |
| ▸ | PTK2 | Q05397 | 1/20 | 0.37 |
| ▸ | DCTPP1 | Q9H773 | 1/20 | 0.37 |
| ▸ | PIM1 | P11309 | 2/20 | 0.36 |
| ▸ | PIM2 | Q9P1W9 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL624008 | 0.83 | PIM1 (0.56) | PIM1PIM2 | |
| SCHEMBL624433 | 0.82 | FYN (0.47) | FYNJAK2JAK3PTK2PIM1 | |
| SCHEMBL624904 | 0.81 | F2RL3 (0.41) | FYNJAK2JAK3PTK2PIM1 | |
| SCHEMBL624902 | 0.77 | FYN (0.54) | FYNPIK3CAGRIN1GRIN2BJAK2 | |
| SCHEMBL623806 | 0.76 | FYN (0.54) | FYNPIM1PIM2 | |
| SCHEMBL15603322 | 0.72 | FYN (0.50) | FYNDCTPP1 | |
| SCHEMBL623882 | 0.72 | DYRK1A (0.46) | FYNPIM1PIM2 | |
| SCHEMBL1946916 | 0.71 | FYN (0.75) | FYNPIM1 | |
| SCHEMBL1946370 | 0.71 | FYN (0.49) | FYN | |
| SCHEMBL625540 | 0.70 | FYN (0.68) | FYN |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012020217-A1 | AMINO- IMIDAZOLOTHIADIAZOLES FOR USE AS PROTEIN OR LIPID KINASE INHIBITORS | CENTRO NACIONAL DE INVESTIGACIONES ONCOLÓGICAS (CNIO) (ES) | 2012-02-16 | — | — | WO | disclosed |