Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 3/20 | 0.64 |
| ▸ | MAPT | P10636 | 4/20 | 0.58 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.58 |
| ▸ | HPGD | P15428 | 1/20 | 0.58 |
| ▸ | RAD52 | P43351 | 1/20 | 0.58 |
| ▸ | ABCG2 | Q9UNQ0 | 2/20 | 0.57 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.55 |
| ▸ | TNFRSF1A | P19438 | 1/20 | 0.55 |
| ▸ | GAA | P10253 | 1/20 | 0.54 |
| ▸ | MEN1 | O00255 | 3/20 | 0.54 |
| ▸ | LMNA | P02545 | 2/20 | 0.54 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.54 |
| ▸ | PDE4A | P27815 | 1/20 | 0.54 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.54 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.54 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.54 |
| ▸ | TP53 | P04637 | 1/20 | 0.54 |
| ▸ | HTT | P42858 | 1/20 | 0.54 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.54 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.54 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1759671 | 0.85 | MAPT (0.66) | NPC1MAPTALDH1A1HPGDABCG2 | |
| SCHEMBL31575666 | 0.84 | NPC1 (0.79) | NPC1MAPTALDH1A1HPGDRAD52 | |
| SCHEMBL285924 | 0.84 | NPC1 (0.79) | NPC1MAPTALDH1A1HPGDRAD52 | |
| SCHEMBL29399711 | 0.82 | NPC1 (0.66) | NPC1MAPTALDH1A1HPGDRAD52 | |
| Peonol Methyl Ether SCHEMBL29402500 | 0.82 | ALDH1A1 (0.67) | NPC1MAPTALDH1A1HPGDRAD52 | |
| SCHEMBL2553094 | 0.82 | NPC1 (0.66) | NPC1MAPTALDH1A1HPGDRAD52 | |
| SCHEMBL154613 | 0.82 | NPC1 (0.66) | NPC1MAPTALDH1A1HPGDRAD52 | |
| Peonol Methyl Ether SCHEMBL4700333 | 0.82 | ALDH1A1 (0.67) | NPC1MAPTALDH1A1HPGDRAD52 | |
| Peonol Methyl Ether SCHEMBL246262 | 0.82 | ALDH1A1 (0.67) | NPC1MAPTALDH1A1HPGDRAD52 | |
| SCHEMBL4900211 | 0.82 | NPC1 (0.66) | NPC1MAPTALDH1A1HPGDRAD52 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 72 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-100509833-C | Macrolides with antibacterial activity | BASILEA PHARMACEUTICA AG (CH) | 2009-07-08 | — | — | CN | claimed |
| US-20080119522-A1 | 5,6-dichloro-2-(2,2,2-trifluoro-ethyl)-1H-benzimidazole for example; use for prostate cancer, benign prostatic hyperplasia (BPH), hirsutism, alopecia, anorexia nervosa, breast cancer, acne, AIDS, cachexia, as a male contraceptive, and/or as a male performance enhancer | NG RAYMOND | 2008-05-22 | — | — | US | claimed |
| EP-1812406-A2 | NOVEL BENZIMIDAZOLE DERIVATIVES USEFUL AS SELECTIVE ANDROGEN RECEPTOR MODULATORS (SARMS) | JANSSEN PHARMACEUTICA N.V. (BE) | 2007-08-01 | — | — | EP | claimed |
| US-20060111402-A1 | Novel benzimidazole derivatives useful as selective androgen receptor modulators (SARMS) | JANSSEN PHARMACEUTICA N.V. (BE) | 2006-05-25 | — | — | US | claimed |
| WO-2006039215-A2 | NOVEL BENZIMIDAZOLE DERIVATIVES USEFUL AS SELECTIVE ANDROGEN RECEPTOR MODULATORS (SARMS) | JANSSEN PHARMACEUTICA N.V. (BE) | 2006-04-13 | — | — | WO | claimed |
| CN-1630661-A | Macrolides with antibacterial activity | BASILEA PHARMACEUTICA AG (CH) | 2005-06-22 | — | — | CN | claimed |
| EP-1192141-A1 | 1,4-DIAZACYCLOHEPTANE DERIVATIVES AS NEUROPROTECTIVE AGENTS | AstraZeneca UK Limited (GB) | 2002-04-03 | — | — | EP | claimed |
| EP-1140863-A1 | 1,4-DIAZACYCLOHEPTANE DERIVATIVES USEFUL IN THE TREATMENT OF NEUROLOGICAL DISORDERS | AstraZeneca AB (SE) | 2001-10-10 | — | — | EP | claimed |
| WO-2000078736-A1 | 1,4-DIAZACYCLOHEPTANE DERIVATIVES AS NEUROPROTECTIVE AGENTS | ASTRAZENECA UK LIMITED (GB) | 2000-12-28 | — | — | WO | claimed |
| WO-2000039105-A1 | 1,4-DIAZACYCLOHEPTANE DERIVATIVES USEFUL IN THE TREATMENT OF NEUROLOGICAL DISORDERS | ASTRAZENECA AB (SE) | 2000-07-06 | — | — | WO | claimed |
| EP-1812406-B1 | NOVEL BENZIMIDAZOLE DERIVATIVES USEFUL AS SELECTIVE ANDROGEN RECEPTOR MODULATORS (SARMS) | JANSSEN PHARMACEUTICA NV (BE) | 2018-09-12 | — | — | EP | disclosed |
| CN-102532162-B | 2,3-dihydro-6-nitroimidazo[2,1-b]oxazoles | OTSUKA PHARMA CO LTD | 2015-05-27 | — | — | CN | disclosed |
| US-8785425-B2 | 11β-hydroxyandrosta-4-ene-3-ones | SUN PHARMA ADVANCED RESEARCH COMPANY LTD. | 2014-07-22 | — | — | US | disclosed |
| EP-1957073-B1 | MEDICINAL DRUG | OTSUKA PHARMA CO LTD (JP) | 2014-04-23 | — | — | EP | disclosed |
| US-8586616-B2 | Benzimidazole derivatives useful as selective androgen receptor modulators (SARMS) | JANSSEN PHARMACEUTICA, NV (BE) | 2013-11-19 | — | — | US | disclosed |
| EP-1192141-A1 | 1,4-DIAZACYCLOHEPTANE DERIVATIVES AS NEUROPROTECTIVE AGENTS | AstraZeneca UK Limited (GB) | 2002-04-03 | — | — | EP | disclosed |
| EP-1140863-A1 | 1,4-DIAZACYCLOHEPTANE DERIVATIVES USEFUL IN THE TREATMENT OF NEUROLOGICAL DISORDERS | AstraZeneca AB (SE) | 2001-10-10 | — | — | EP | disclosed |
| WO-2000078736-A1 | 1,4-DIAZACYCLOHEPTANE DERIVATIVES AS NEUROPROTECTIVE AGENTS | ASTRAZENECA UK LIMITED (GB) | 2000-12-28 | — | — | WO | disclosed |
| WO-2000039105-A1 | 1,4-DIAZACYCLOHEPTANE DERIVATIVES USEFUL IN THE TREATMENT OF NEUROLOGICAL DISORDERS | ASTRAZENECA AB (SE) | 2000-07-06 | — | — | WO | disclosed |
| US-3971825-A | (5,6) (10,11) BIS-METHYLENE, BRONCHODILATORS | SANKYO COMPANY LIMITED (JA) | 1976-07-27 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20060111402-A1 | Novel benzimidazole derivatives useful as selective androgen receptor modulators (SARMS) | AR, NR5A1, ESRRA | NPC1 1130/4885MAPT 2134/4885ALDH1A1 752/4885 |
| US-20080119522-A1 | 5,6-dichloro-2-(2,2,2-trifluoro-ethyl)-1H-benzimidazole for example; use for prostate cancer, benign prostatic hyperplasia (BPH), hirsutism, alopecia, anorexia nervosa, breast cancer, acne, AIDS, cachexia, as a male contraceptive, and/or as a male performance enhancer | AR, FSHR, BRDT | NPC1 1348/4885MAPT 3096/4885ALDH1A1 888/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.