Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FYN | P06241 | 5/20 | 0.47 |
| ▸ | F2RL3 | Q96RI0 | 5/20 | 0.36 |
| ▸ | JAK2 | O60674 | 1/20 | 0.35 |
| ▸ | JAK3 | P52333 | 1/20 | 0.35 |
| ▸ | PTK2 | Q05397 | 1/20 | 0.35 |
| ▸ | TP53 | P04637 | 4/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.34 |
| ▸ | NPC1 | O15118 | 3/20 | 0.34 |
| ▸ | RAB9A | P51151 | 3/20 | 0.34 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.34 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.34 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.34 |
| ▸ | RELA | Q04206 | 1/20 | 0.34 |
| ▸ | AURKA | O14965 | 1/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.33 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.33 |
| ▸ | MAPT | P10636 | 2/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | GFER | P55789 | 1/20 | 0.33 |
| ▸ | DCTPP1 | Q9H773 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL624979 | 0.85 | ADORA2A (0.38) | F2RL3TP53HSD17B10 | |
| SCHEMBL625549 | 0.84 | F2RL3 (0.51) | F2RL3AURKA | |
| SCHEMBL625540 | 0.82 | FYN (0.68) | FYN | |
| SCHEMBL625561 | 0.82 | PIM1 (0.49) | F2RL3 | |
| SCHEMBL1944344 | 0.81 | FYN (0.67) | FYNF2RL3TP53SMN1; SMN2NPC1 | |
| SCHEMBL626108 | 0.74 | MAP3K12 (0.42) | — | |
| SCHEMBL624904 | 0.72 | F2RL3 (0.41) | FYNF2RL3JAK2JAK3PTK2 | |
| SCHEMBL1946623 | 0.71 | RAB9A (0.47) | FYNF2RL3TP53SMN1; SMN2NPC1 | |
| SCHEMBL1948061 | 0.71 | FYN (0.48) | FYNF2RL3TP53SMN1; SMN2NPC1 | |
| SCHEMBL1946917 | 0.71 | FYN (0.52) | FYNF2RL3TP53 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012020217-A1 | AMINO- IMIDAZOLOTHIADIAZOLES FOR USE AS PROTEIN OR LIPID KINASE INHIBITORS | CENTRO NACIONAL DE INVESTIGACIONES ONCOLÓGICAS (CNIO) (ES) | 2012-02-16 | — | — | WO | disclosed |