Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 3/20 | 0.57 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.57 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.57 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.52 |
| ▸ | TSHR | P16473 | 2/20 | 0.52 |
| ▸ | POLB | P06746 | 5/20 | 0.51 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.51 |
| ▸ | RAB9A | P51151 | 2/20 | 0.50 |
| ▸ | GRIK1 | P39086 | 1/20 | 0.50 |
| ▸ | NPC1 | O15118 | 1/20 | 0.50 |
| ▸ | THRB | P10828 | 1/20 | 0.50 |
| ▸ | NOX1 | Q9Y5S8 | 1/20 | 0.50 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.50 |
| ▸ | LMNA | P02545 | 1/20 | 0.49 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.47 |
| ▸ | GAA | P10253 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9725165 | 0.80 | SMN1; SMN2 (0.44) | MEN1KMT2AALDH1A1TSHRRAB9A | |
| SCHEMBL2196592 | 0.77 | DDX3X (0.55) | MEN1KMT2AALDH1A1POLBRAB9A | |
| SCHEMBL4067352 | 0.77 | CA12 (0.52) | MEN1KMT2ATSHRGRIK1TRPV1 | |
| SCHEMBL7759976 | 0.76 | MEN1 (0.68) | MEN1KMT2AKDM4EALDH1A1TSHR | |
| SCHEMBL6567619 | 0.76 | KMT2A (0.65) | MEN1KMT2AKDM4EALDH1A1TSHR | |
| SCHEMBL194876 | 0.74 | MEN1 (0.62) | MEN1KMT2AKDM4EALDH1A1TSHR | |
| SCHEMBL22103682 | 0.74 | ALDH1A1 (0.66) | MEN1KMT2AKDM4EALDH1A1TSHR | |
| SCHEMBL1462231 | 0.74 | GRIK1 (0.72) | MEN1KMT2AKDM4EALDH1A1TSHR | |
| SCHEMBL5481186 | 0.73 | RAB9A (0.34) | KDM4EALDH1A1TSHRPOLBRAB9A | |
| Hydrochloric Acid SCHEMBL9004750 | 0.73 | MEN1 (0.60) | MEN1KMT2AKDM4EALDH1A1TSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1537112-A1 | CONDENSED PYRIDINES AND PYRIMIDINES WITH TIE2 (TEK) ACTIVITY | Astrazeneca AB (SE) | 2005-06-08 | — | — | EP | disclosed |
| WO-2004013141-A1 | CONDENSED PYRIDINES AND PYRIMIDINES WITH TIE2 (TEK) ACTIVITY | ASTRAZENECA AB (SE) | 2004-02-12 | — | — | WO | disclosed |