Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRM4 | Q14833 | 2/20 | 0.54 |
| ▸ | NR3C1 | P04150 | 2/20 | 0.43 |
| ▸ | CTNNB1 | P35222 | 1/20 | 0.40 |
| ▸ | WNT3A | P56704 | 1/20 | 0.40 |
| ▸ | VNN1 | O95497 | 1/20 | 0.39 |
| ▸ | HSD17B14 | Q9BPX1 | 1/20 | 0.39 |
| ▸ | KCNN4 | O15554 | 2/20 | 0.37 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.37 |
| ▸ | CETP | P11597 | 1/20 | 0.37 |
| ▸ | PDE2A | O00408 | 1/20 | 0.37 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.36 |
| ▸ | SLC22A12 | Q96S37 | 1/20 | 0.36 |
| ▸ | KMO | O15229 | 1/20 | 0.36 |
| ▸ | IDO1 | P14902 | 1/20 | 0.36 |
| ▸ | GAA | P10253 | 1/20 | 0.36 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.36 |
| ▸ | TLR7 | Q9NYK1 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL625389 | 0.91 | HDAC1 (0.46) | GRM4NR3C1CTNNB1WNT3AHSD17B14 | |
| SCHEMBL626126 | 0.87 | HSD17B14 (0.43) | GRM4NR3C1CTNNB1WNT3AHSD17B14 | |
| SCHEMBL14893822 | 0.82 | TLR7 (0.40) | GRM4CTNNB1WNT3AHDAC4TLR7 | |
| SCHEMBL15011536 | 0.82 | TLR7 (0.51) | GRM4NR3C1PDE2ATLR7 | |
| SCHEMBL624174 | 0.81 | TLR7 (0.50) | NR3C1VNN1HDAC1SLC22A12TLR7 | |
| SCHEMBL624708 | 0.81 | TLR7 (0.44) | GRM4CTNNB1WNT3APDE2ATDP1 | |
| SCHEMBL624803 | 0.80 | HDAC4 (0.53) | GRM4CTNNB1WNT3AHDAC1HDAC4 | |
| SCHEMBL625186 | 0.80 | P2RX7 (0.46) | NR3C1IDO1GAATLR7 | |
| SCHEMBL15011470 | 0.79 | P2RX7 (0.50) | HDAC1IDO1GAATDP1TLR7 | |
| SCHEMBL625121 | 0.79 | TLR7 (0.41) | GRM4NR3C1CTNNB1WNT3APDE2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9156788-B2 | TRPV3 modulators | ABBVIE INC. (US) | 2015-10-13 | — | — | US | disclosed |
| EP-2603490-A1 | NOVEL TRPV3 MODULATORS | AbbVie Inc. (US) | 2013-06-19 | — | — | EP | disclosed |
| US-20130150409-A1 | NOVEL TRPV3 MODULATORS | ABBVIE INC. (US) | 2013-06-13 | — | — | US | disclosed |
| WO-2012019315-A1 | NOVEL TRPV3 MODULATORS | ABBOTT LABORATORIES (US) | 2012-02-16 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20130150409-A1 | NOVEL TRPV3 MODULATORS | TRPV3, TRPV4, TRPV5 | GRM4 242/4885NR3C1 469/4885CTNNB1 1897/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.