Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SIGMAR1 | Q99720 | 9/20 | 1.00 |
| ▸ | DRD2 | P14416 | 1/20 | 0.66 |
| ▸ | DRD4 | P21917 | 1/20 | 0.66 |
| ▸ | DRD3 | P35462 | 1/20 | 0.66 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.66 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4254894 | 0.95 | SIGMAR1 (1.00) | SIGMAR1DRD2DRD4DRD3KCNH2 | |
| SCHEMBL8084143 | 0.93 | SIGMAR1 (1.00) | SIGMAR1 | |
| SCHEMBL9768701 | 0.93 | SIGMAR1 (0.86) | SIGMAR1KCNH2 | |
| SCHEMBL2538905 | 0.93 | SIGMAR1 (0.95) | SIGMAR1DRD2DRD4DRD3KCNH2 | |
| SCHEMBL10453660 | 0.93 | SIGMAR1 (0.91) | SIGMAR1DRD3KCNH2 | |
| SCHEMBL8091327 | 0.91 | SIGMAR1 (1.00) | SIGMAR1 | |
| SCHEMBL7369457 | 0.91 | SIGMAR1 (1.00) | SIGMAR1 | |
| SCHEMBL20689719 | 0.91 | SIGMAR1 (0.91) | SIGMAR1DRD3KCNH2 | |
| SCHEMBL7272554 | 0.91 | SIGMAR1 (0.91) | SIGMAR1DRD3KCNH2 | |
| SCHEMBL8092310 | 0.91 | SIGMAR1 (0.95) | SIGMAR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 27 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2661436-B1 | NOVEL SULFAMIDE PIPERAZINE DERIVATIVES AS PROTEIN TYROSINE KINASE INHIBITORS AND PHARMACEUTICAL USE THEREOF | LEO PHARMA AS (DK) | 2016-04-13 | — | — | EP | claimed |
| US-6057371-A | TREATMENT OF CENTRAL NERVOUS SYSTEM DISORDERS, GASTROINTESTINAL DISORDERS, DRUG ABUSE, ANGINA, MIGRAINE, HYPERTENSION AND DEPRESSION | VIRGINIA COMMONWEALTH UNIVERSITY (US) | 2000-05-02 | — | — | US | claimed |
| EP-0591426-A1 | SIGMA RECEPTOR LIGANDS AND THE USE THEREOF | VIRGINIA COMMONWEALTH UNIVERSITY (US) | 1994-04-13 | — | — | EP | claimed |
| WO-1993000313-A2 | SIGMA RECEPTOR LIGANDS AND THE USE THEREOF | VIRGINIA COMMONWEALTH UNIVERSITY (US) | 1993-01-07 | — | — | WO | claimed |
| WO-1991009594-A1 | SIGMA RECEPTOR LIGANDS AND THE USE THEREOF | VIRGINIA COMMONWEALTH UNIVERSITY (US) | 1991-07-11 | — | — | WO | claimed |
| US-11161827-B2 | Catalytic systems for stereoselective synthesis of chiral amines by enantiodivergent radical C—H amination | THE TRUSTEES OF BOSTON COLLEGE (MA) | 2021-11-02 | — | — | US | disclosed |
| US-11161827-B2 | Catalytic systems for stereoselective synthesis of chiral amines by enantiodivergent radical C—H amination | THE TRUSTEES OF BOSTON COLLEGE (MA) | 2021-11-02 | — | — | US | disclosed |
| US-20200317627-A1 | CATALYTIC SYSTEMS FOR STEREOSELECTIVE SYNTHESIS OF CHIRAL AMINES BY ENANTIODIVERGENT RADICAL C-H AMINATION | TRUSTEES OF BOSTON COLLEGE (US) | 2020-10-08 | — | — | US | disclosed |
| US-20200317627-A1 | CATALYTIC SYSTEMS FOR STEREOSELECTIVE SYNTHESIS OF CHIRAL AMINES BY ENANTIODIVERGENT RADICAL C-H AMINATION | TRUSTEES OF BOSTON COLLEGE (US) | 2020-10-08 | — | — | US | disclosed |
| EP-1957507-B1 | ANTIBACTERIAL 4,5-SUBSTITUTED AMINOGLYCOSIDE ANALOGS HAVING MULTIPLE SUBSTITUENTS | IONIS PHARMACEUTICALS INC (US) | 2018-10-24 | — | — | EP | disclosed |
| US-8569264-B2 | Antibacterial 4,5-substituted aminoglycoside analogs having multiple substituents | ISIS PHARMACEUTICALS, INC. (US) | 2013-10-29 | — | — | US | disclosed |
| WO-2013022763-A1 | GLYCOPEPTIDE ANTIBIOTIC ANALOGS EFFECTIVE AGAINST VANCOMYCIN-RESISTANT BACTERIAL STRAINS | THE SCRIPPS RESEARCH INSTITUTE (US) | 2013-02-14 | — | — | WO | disclosed |
| US-20080045468-A1 | ANTIMICROBIAL 2-DEOXYSTREPTAMINE COMPOUNDS | ISIS PHARMACEUTICALS, INC. (US) | 2008-02-21 | — | — | US | disclosed |
| EP-1809645-A1 | ANTIMICROBIAL 2-DEOXYSTREPTAMINE COMPOUNDS | Isis Pharmaceuticals, Inc. (US) | 2007-07-25 | — | — | EP | disclosed |
| WO-2007064954-A2 | ANTIBACTERIAL 4,5-SUBSTITUTED AMINOGLYCOSIDE ANALOGS HAVING MULTIPLE SUBSTITUENTS | ISIS PHARMACEUTICALS, INC. (US) | 2007-06-07 | — | — | WO | disclosed |
| WO-2006052930-A1 | ANTIMICROBIAL 2-DEOXYSTREPTAMINE COMPOUNDS | ISIS PHARMACEUTICALS, INC. (US) | 2006-05-18 | — | — | WO | disclosed |
| US-5663148-A | ANTIINFLAMMATORY AGENTS OF OLIGOPEPTIDES FOR BACTERICIDES, FUNGICIDES, ANTICARCINOGENIC AGENTS, VIRICIDES OR AUTOIMMUNE DISEASES | ABBOTT LABORATORIES (US) | 1997-09-02 | — | — | US | disclosed |
| WO-1997023202-A1 | SUBTYPE-SELECTIVE NMDA RECEPTOR LIGANDS AND THE USE THEREOF | STATE OF OREGON, acting by and through THE OREGON STATE BOARD OF HIGHER EDUCATION, acting for and on behalf of THE OREGON HEALTH SCIENCES UNIVERSITYA ND THE UNIVERSITY OF OREGON, EUGENE OREGON (US) | 1997-07-03 | — | — | WO | disclosed |
| WO-1994007815-A2 | SMALL PEPTIDE ANAPHYLATOXIN RECEPTOR LIGANDS | ABBOTT LABORATORIES (US) | 1994-04-14 | — | — | WO | disclosed |
| WO-1994007518-A1 | ANAPHYLATOXIN RECEPTOR LIGANDS CONTAINING LIPOPHILIC RESIDUES | ABBOTT LABORATORIES (US) | 1994-04-14 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-11161827-B2 | Catalytic systems for stereoselective synthesis of chiral amines by enantiodivergent radical C—H amination | STS, SRM, SCLY | SIGMAR1 249/4885DRD2 236/4885DRD4 134/4885 |
| US-20080045468-A1 | ANTIMICROBIAL 2-DEOXYSTREPTAMINE COMPOUNDS | MTAP, UNG, PNMT | SIGMAR1 802/4885DRD2 27/4885DRD4 47/4885 |
| US-20200317627-A1 | CATALYTIC SYSTEMS FOR STEREOSELECTIVE SYNTHESIS OF CHIRAL AMINES BY ENANTIODIVERGENT RADICAL C-H AMINATION | STS, SCLY, SRM | SIGMAR1 240/4885DRD2 247/4885DRD4 140/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.