SCHEMBL6253989

SCHEMBL6253989

Fc1cc(NCC2CC3CCC(C2)N3Cc2ccc(C(F)(F)F)cc2)ccc1N1CCOCC1

nearest known ligand 0.44

Predicted protein targets (top 18)

geneUniProtsupporting neighboursconfidence
LDHA P00338 2/20 0.44
LDHB P07195 2/20 0.44
HTT P42858 2/20 0.41
LTA4H P09960 1/20 0.40
CYP2C9 P11712 1/20 0.39
HIF1A Q16665 3/20 0.39
EPAS1 Q99814 3/20 0.39
KDM4E B2RXH2 2/20 0.39
ALDH1A1 P00352 1/20 0.39
LMNA P02545 1/20 0.39
ALDH2 P05091 1/20 0.39
SRPK1 Q96SB4 1/20 0.38
TSHR P16473 1/20 0.38
NPSR1 Q6W5P4 1/20 0.38
NPC1 O15118 2/20 0.38
RAB9A P51151 2/20 0.38
GAA P10253 2/20 0.38
KMT2A Q03164 1/20 0.38

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Hydrochloric Acid SCHEMBL6259317 0.99 LDHA (0.44) LDHALDHBHTTLTA4HCYP2C9
SCHEMBL8287911 0.92 MAOA (0.42) LDHALDHBHTTCYP2C9KDM4E
SCHEMBL6272358 0.91 LDHA (0.43) LDHALDHBHTTKDM4EALDH1A1
SCHEMBL8288813 0.90 P2RX3 (0.43) HTTKDM4EALDH1A1LMNAALDH2
SCHEMBL8278360 0.86 HIF1A (0.48) LDHALDHBHTTCYP2C9HIF1A
SCHEMBL6272361 0.83 LDHA (0.50) LDHALDHBHTTKDM4EALDH1A1
SCHEMBL8289194 0.82 LDHA (0.49) LDHALDHBHTTKDM4EALDH1A1
SCHEMBL4414914 0.80 HIF1A (0.47) LDHALDHBHTTCYP2C9HIF1A
SCHEMBL8289912 0.80 LDHA (0.45) LDHALDHBHTTCYP2C9HIF1A
SCHEMBL8287900 0.77 PDE10A (0.39) HTTKDM4EALDH1A1LMNATSHR

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2005058317-A1 GLYCINE TRANSPORTER-1 INHIBIRORS GLAXO GROUP LIMITED (GB) 2005-06-30 WO disclosed
WO-2005058317-A1 GLYCINE TRANSPORTER-1 INHIBIRORS GLAXO GROUP LIMITED (GB) 2005-06-30 WO disclosed