SCHEMBL6254489

SCHEMBL6254489

CC(C)(C)c1ccccc1C1=C(c2ccccc2C(C)(C)C)[Si](C)(C)C(c2ccccc2C(C)(C)C)=C1c1ccccc1C(C)(C)C

nearest known ligand 0.39

Predicted protein targets (top 8)

geneUniProtsupporting neighboursconfidence
ALDH1A1 P00352 1/20 0.39
TSHR P16473 1/20 0.39
TDP1 Q9NUW8 1/20 0.39
CA2 P00918 1/20 0.35
TRPA1 O75762 1/20 0.34
GABRA1 P14867 1/20 0.31
GABRB2 P47870 1/20 0.31
KIF11 P52732 1/20 0.31

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL6257021 0.82 ALDH1A1 (0.34) ALDH1A1TSHRTDP1CA2TRPA1
SCHEMBL6254918 0.81 ALDH1A1 (0.36) ALDH1A1TSHRTDP1CA2TRPA1
SCHEMBL6253609 0.79 ALDH1A1 (0.35) ALDH1A1TSHRTDP1CA2TRPA1
SCHEMBL1194484 0.75 ALDH1A1 (0.55) ALDH1A1TSHRTDP1CA2TRPA1
Phosphine SCHEMBL2238711 0.73 ALDH1A1 (0.52) ALDH1A1TSHRTDP1CA2TRPA1
SCHEMBL545684 0.73 ALDH1A1 (0.52) ALDH1A1TSHRTDP1CA2TRPA1
SCHEMBL11020611 0.71 ALDH1A1 (0.50) ALDH1A1TSHRTDP1CA2TRPA1
SCHEMBL6253882 0.71 HSD11B1 (0.46) ALDH1A1TRPA1
SCHEMBL17739671 0.68 CA2 (0.44) ALDH1A1TSHRTDP1CA2TRPA1
SCHEMBL6252883 0.68 TSHR (0.39) ALDH1A1TSHRCA2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1143538-B1 Organic electroluminescent element containing a silacyclopentadiene derivative CHISSO CORP (JP) 2005-09-14 EP disclosed
EP-0754691-B1 Silacyclopentadiene derivatives and an organic electroluminescent element obtained by using the silacyclopentadiene derivative CHISSO CORP (JP) 2003-11-19 EP disclosed
EP-1143538-A1 Silacyclopentadiene derivatives and an organic electroluminescent element obtained by using the silacyclopentadiene derivative Chisso Corporation (JP) 2001-10-10 EP disclosed
US-6051319-A Silacyclopentadiene derivatives and an organic electroluminescent element obtained by using the silacyclopentadiene derivative CHISSO CORPORATION (JP) 2000-04-18 US disclosed
US-5986121-A Silacyclopentadiene derivatives and an organic electroluminescent element obtained by using the silacyclopentadiene derivative CHISSO CORPORATION (JP) 1999-11-16 US disclosed
EP-0754691-A2 Silacyclopentadiene derivatives and an organic electroluminescent element obtained by using the silacyclopentadiene derivative CHISSO CORPORATION (JP) 1997-01-22 EP disclosed