Known targets — ChEMBL curated mechanism
AGTR1DHFRGABBR1GABBR2GABRA1GABRA2GABRA3GABRA4GABRA5GABRA6GABRB1GABRB2GABRB3GABRDGABREGABRG1GABRG2GABRG3GABRPGABRQGARTNR3C2PBP2XPTGS1PTGS2VKORC1blablaT-3blaT-4blaT-5blaT-6dacAdacBdacCfolAftsImrcAmrcBmrdApbp1apbp1bpbp2apbp2bpbp3polthyA
The experimentally established mechanism targets of Potassium Ion. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 1/20 | 0.65 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.63 |
| ▸ | CTSD | P07339 | 1/20 | 0.59 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.57 |
| ▸ | GAA | P10253 | 2/20 | 0.57 |
| ▸ | MAPT | P10636 | 2/20 | 0.57 |
| ▸ | MEN1 | O00255 | 1/20 | 0.57 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.57 |
| ▸ | DTYMK | P23919 | 1/20 | 0.53 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.52 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.51 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.51 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.51 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.51 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.51 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.50 |
| ▸ | ALPL | P05186 | 1/20 | 0.50 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.50 |
| ▸ | HTT | P42858 | 1/20 | 0.50 |
| ▸ | NCOA1 | Q15788 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL78205 | 0.98 | TSHR (0.67) | TSHRALDH1A1CTSDKDM4EGAA | |
| SCHEMBL29696138 | 0.98 | TSHR (0.67) | TSHRALDH1A1CTSDKDM4EGAA | |
| SCHEMBL30727560 | 0.98 | TSHR (0.67) | TSHRALDH1A1CTSDKDM4EGAA | |
| Ammonia Solution, Strong SCHEMBL11058598 | 0.96 | TSHR (0.65) | TSHRALDH1A1CTSDKDM4EGAA | |
| SCHEMBL4588668 | 0.96 | TSHR (0.65) | TSHRALDH1A1CTSDKDM4EGAA | |
| SCHEMBL625577 | 0.96 | TSHR (0.65) | TSHRALDH1A1CTSDKDM4EGAA | |
| SCHEMBL4587804 | 0.96 | TSHR (0.65) | TSHRALDH1A1CTSDKDM4EGAA | |
| SCHEMBL6391676 | 0.96 | TSHR (0.65) | TSHRALDH1A1CTSDKDM4EGAA | |
| SCHEMBL9125306 | 0.96 | TSHR (0.65) | TSHRALDH1A1CTSDKDM4EGAA | |
| SCHEMBL20377950 | 0.96 | TSHR (0.65) | TSHRALDH1A1CTSDKDM4EGAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 11 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10995365-B2 | Compounds and systems for improving signal detection | PACIFIC BIOSCIENCES OF CALIFORNIA, INC. | 2021-05-04 | — | — | US | disclosed |
| EP-3350350-B1 | COMPOUNDS AND SYSTEMS FOR IMPROVING SIGNAL DETECTION | PACIFIC BIOSCIENCES CALIFORNIA INC (US) | 2021-04-14 | — | — | EP | disclosed |
| US-10435741-B2 | Compounds and systems for improving signal detection | PACIFIC BIOSCIENCES OF CALIFORNIA, INC. (US) | 2019-10-08 | — | — | US | disclosed |
| US-20190106742-A1 | COMPOUNDS AND SYSTEMS FOR IMPROVING SIGNAL DETECTION | PACIFIC BIOSCIENCES CALIFORNIA INC (US) | 2019-04-11 | — | — | US | disclosed |
| EP-3350350-A1 | COMPOUNDS AND SYSTEMS FOR IMPROVING SIGNAL DETECTION | Pacific Biosciences of California, Inc. (US) | 2018-07-25 | — | — | EP | disclosed |
| US-9732382-B2 | Photodamage mitigation compounds and systems | PACIFIC BIOSCIENCES OF CALIFORNIA, INC. (US) | 2017-08-15 | — | — | US | disclosed |
| US-20170145494-A1 | COMPOUNDS AND SYSTEMS FOR IMPROVING SIGNAL DETECTION | PACIFIC BIOSCIENCES OF CALIFORNIA, INC. | 2017-05-25 | — | — | US | disclosed |
| US-20150079603-A1 | PHOTODAMAGE MITIGATION COMPOUNDS AND SYSTEMS | PACIFIC BIOSCIENCES CALIFORNIA (US) | 2015-03-19 | — | — | US | disclosed |
| US-8834847-B2 | Photodamage mitigation compounds and systems | PACIFIC BIOSCIENCES OF CALIFORNIA, INC. (US) | 2014-09-16 | — | — | US | disclosed |
| US-20120052488-A1 | PHOTODAMAGE MITIGATION COMPOUNDS AND SYSTEMS | PACIFIC BIOSCIENCES OF CALIFORNIA, INC. (US) | 2012-03-01 | — | — | US | disclosed |
| WO-2012021733-A2 | PHOTODAMAGE MITIGATION COMPOUNDS AND SYSTEMS | PACIFIC BIOSCIENCES OF CALIFORNIA, INC. (US) | 2012-02-16 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120052488-A1 | PHOTODAMAGE MITIGATION COMPOUNDS AND SYSTEMS | CRY1, ERCC1, ERCC4 | TSHR 3233/4885ALDH1A1 814/4885CTSD 1959/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.