Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 2/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.43 |
| ▸ | PSMB1 | P20618 | 1/20 | 0.41 |
| ▸ | PSMB5 | P28074 | 1/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.39 |
| ▸ | HPGD | P15428 | 2/20 | 0.39 |
| ▸ | CACNA1B | Q00975 | 1/20 | 0.38 |
| ▸ | PDE9A | O76083 | 2/20 | 0.37 |
| ▸ | CCNE2 | O96020 | 1/20 | 0.37 |
| ▸ | CDK4 | P11802 | 1/20 | 0.37 |
| ▸ | CCND1 | P24385 | 1/20 | 0.37 |
| ▸ | CCNE1 | P24864 | 1/20 | 0.37 |
| ▸ | CDK2 | P24941 | 1/20 | 0.37 |
| ▸ | THRB | P10828 | 1/20 | 0.36 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.36 |
| ▸ | POLB | P06746 | 1/20 | 0.36 |
| ▸ | KDM5B | Q9UGL1 | 1/20 | 0.36 |
| ▸ | NPBWR1 | P48145 | 1/20 | 0.36 |
| ▸ | DPP4 | P27487 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6260924 | 0.88 | MEN1 (0.43) | MEN1KMT2APSMB1PSMB5KDM4E | |
| SCHEMBL6254631 | 0.82 | CASP3 (0.46) | MEN1KMT2APSMB1PSMB5KDM4E | |
| SCHEMBL6258737 | 0.81 | PTGIR (0.47) | PSMB5KDM4EALDH1A1HPGDNPBWR1 | |
| SCHEMBL6260233 | 0.80 | GRM2 (0.47) | MEN1KMT2APSMB1PSMB5KDM4E | |
| SCHEMBL6256484 | 0.80 | KDM4E (0.43) | MEN1KMT2APSMB1PSMB5KDM4E | |
| SCHEMBL6259201 | 0.79 | KDM4E (0.43) | MEN1KMT2APSMB1PSMB5KDM4E | |
| SCHEMBL6254976 | 0.77 | KDM4E (0.41) | PSMB1PSMB5KDM4EALDH1A1HPGD | |
| SCHEMBL6254981 | 0.77 | KDM4E (0.48) | MEN1KMT2APSMB1PSMB5KDM4E | |
| SCHEMBL6257629 | 0.77 | POLB (0.56) | MEN1KMT2AKDM4EALDH1A1HPGD | |
| SCHEMBL7730189 | 0.74 | MEN1 (0.44) | MEN1KMT2APSMB1PSMB5KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1156039-B1 | PYRIDAZIN-3-ONE DERIVATIVES AND MEDICINES CONTAINING THE SAME | KOWA CO (JP) | 2005-10-05 | — | — | EP | disclosed |
| US-6680316-B1 | INTERLEUKIN INHIBITORS; AUTOIMMUNE, RHEUMATIC, AND GASTROINTESTINAL DISORDERS; OSTEOPOROSIS; ANTIINFLAMMATORY, ANTIISCHEMIC, AND ANTIARTHRITIC AGENTS | KOWA CO., LTD. (JP) | 2004-01-20 | — | — | US | disclosed |
| EP-1156039-A1 | PYRIDAZIN-3-ONE DERIVATIVES AND MEDICINES CONTAINING THE SAME | Kowa Co., Ltd. (JP) | 2001-11-21 | — | — | EP | disclosed |