Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 6/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.44 |
| ▸ | HPGD | P15428 | 5/20 | 0.44 |
| ▸ | HSD17B10 | Q99714 | 5/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.44 |
| ▸ | GAA | P10253 | 2/20 | 0.44 |
| ▸ | NISCH | Q9Y2I1 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.37 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.37 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.37 |
| ▸ | TSHR | P16473 | 2/20 | 0.37 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.37 |
| ▸ | TP53 | P04637 | 1/20 | 0.37 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.37 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.37 |
| ▸ | RELA | Q04206 | 1/20 | 0.37 |
| ▸ | ATM | Q13315 | 1/20 | 0.37 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.36 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.36 |
| ▸ | NPC1 | O15118 | 2/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2586684 | 0.91 | HPRT1 (0.47) | MAPTALDH1A1HPGDHSD17B10KDM4E | |
| SCHEMBL5984762 | 0.85 | IKBKE (0.44) | MAPTALDH1A1HPGDHSD17B10KDM4E | |
| SCHEMBL11728712 | 0.78 | AKR1C3 (0.42) | MAPTALDH1A1HPGDHSD17B10KDM4E | |
| SCHEMBL7972358 | 0.78 | CYP2A6 (0.38) | ALDH1A1HPGDSMN1; SMN2TP53NPC1 | |
| SCHEMBL28855694 | 0.75 | TYMP (0.40) | MAPTALDH1A1HPGDHSD17B10KDM4E | |
| SCHEMBL2958656 | 0.72 | CA1 (0.36) | MAPTALDH1A1HPGDHSD17B10KDM4E | |
| SCHEMBL9867507 | 0.72 | KDM4E (0.39) | MAPTALDH1A1HPGDHSD17B10KDM4E | |
| SCHEMBL1018789 | 0.71 | ALOX5 (0.46) | MAPTALDH1A1HPGDHSD17B10KDM4E | |
| SCHEMBL5814878 | 0.70 | CHRM2 (0.40) | MAPTALDH1A1HPGDKDM4ETDP1 | |
| SCHEMBL7980848 | 0.70 | MAOB (0.31) | MAOB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 11 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2013070655-A1 | METHOD OF INCREASING THE PERFORMANCE OF CATIONIC FABRIC SOFTENERS | THE DIAL CORPORATION (US) | 2013-05-16 | — | — | WO | claimed |
| EP-1284257-B1 | Difluoromethylene aromatic ethers and their use as inhibitors of the glycine type-1 transporter | PFIZER PROD INC (US) | 2005-10-05 | — | — | EP | disclosed |
| US-6784299-B2 | CARBOCYCLIC ETHERS SUCH AS (METHYL-(3-(4-PHENOXY-PHENOXY)-3-PHENYL-PROPYL)-AMINO)-ACETIC ACID, USED AS NEUROTRANSMITTER ANTAGONISTS, FOR PROPHYLAXIS OF PSYCHOLOGICAL DISORDERS | PFIZER INC. | 2004-08-31 | — | — | US | disclosed |
| EP-1406861-A1 | SUBSTITUTED AROMATIC ETHERS AS INHIBITORS OF GLYCINE TRANSPORT | Pfizer Products Inc. (US) | 2004-04-14 | — | — | EP | disclosed |
| US-6710071-B2 | SUCH AS ((3-4-(DIFLUORO(PHENYL)METHYL)PHENOXYL-3-PHENYLPROPYL)METHYLAMINO)ACETIC ACID; FOR THE ENHANCEMENT OF COGNITION AND THE TREATMENT OF SCIZOPHRENIA AND OTHER PSYCHOSES | PFIZER INC | 2004-03-23 | — | — | US | disclosed |
| US-20030208081-A1 | Substituted aromatic ethers as inhibitors of glycine transport | PFIZER INC. | 2003-11-06 | — | — | US | disclosed |
| US-6566550-B2 | Such as (methyl-(3-phenyl-3(4-(3-trifluoromethylphenoxy) phenoxy)propyl)amino)acetic acid for treatment of mental disorders | PFIZER INC | 2003-05-20 | — | — | US | disclosed |
| US-20030045569-A1 | Difluoromethylene aromatic ethers as inhibitors of glycine transport | PFIZER INC. | 2003-03-06 | — | — | US | disclosed |
| EP-1284257-A2 | Difluoromethylene aromatic ethers and their use as inhibitors of the glycine type-1 transporter | Pfizer Products Inc. (US) | 2003-02-19 | — | — | EP | disclosed |
| US-20030013887-A1 | Such as (methyl-(3-phenyl-3(4-(3-trifluoromethylphenoxy) phenoxy)propyl)amino)acetic acid for treatment of mental disorders | PFIZER INC. | 2003-01-16 | — | — | US | disclosed |
| WO-2003000646-A1 | SUBSTITUTED AROMATIC ETHERS AS INHIBITORS OF GLYCINE TRANSPORT | PFIZER PRODUCTS INC. (US) | 2003-01-03 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20030013887-A1 | Such as (methyl-(3-phenyl-3(4-(3-trifluoromethylphenoxy) phenoxy)propyl)amino)acetic acid for treatment of mental disorders | SLC1A2, SLC1A1, SLC1A3 | MAPT 797/4885ALDH1A1 1330/4885HPGD 2163/4885 |
| US-20030045569-A1 | Difluoromethylene aromatic ethers as inhibitors of glycine transport | SLC1A2, SLC1A1, SLC1A3 | MAPT 883/4885ALDH1A1 1745/4885HPGD 2941/4885 |
| US-20030208081-A1 | Substituted aromatic ethers as inhibitors of glycine transport | SLC1A2, SLC1A1, SLC6A1 | MAPT 665/4885ALDH1A1 2156/4885HPGD 2673/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.