Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FYN | P06241 | 8/20 | 0.56 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.43 |
| ▸ | HASPIN | Q8TF76 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 2/20 | 0.43 |
| ▸ | THRB | P10828 | 1/20 | 0.43 |
| ▸ | KCNH2 | Q12809 | 4/20 | 0.43 |
| ▸ | LMNA | P02545 | 1/20 | 0.42 |
| ▸ | NR2F2 | P24468 | 1/20 | 0.42 |
| ▸ | RAB9A | P51151 | 1/20 | 0.42 |
| ▸ | GSK3B | P49841 | 1/20 | 0.42 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL624949 | 0.91 | FYN (0.55) | FYNPIK3CAHASPINKCNH2NR2F2 | |
| SCHEMBL625664 | 0.83 | MAPT (0.58) | MAPTTHRB | |
| SCHEMBL625746 | 0.79 | PIK3CA (0.54) | PIK3CAHASPINKCNH2 | |
| SCHEMBL627054 | 0.78 | KDM4E (0.48) | KDM4EMAPTTHRBLMNA | |
| SCHEMBL626697 | 0.75 | CYP11B2 (0.53) | FYNPIK3CAHASPIN | |
| SCHEMBL624950 | 0.74 | MAPT (0.56) | MAPTTHRB | |
| SCHEMBL18613694 | 0.72 | FYN (1.00) | FYNHASPIN | |
| SCHEMBL1945183 | 0.72 | FYN (0.58) | FYNPIK3CA | |
| SCHEMBL1944166 | 0.71 | FYN (0.81) | FYNPIK3CAHASPIN | |
| SCHEMBL1945181 | 0.71 | FYN (0.87) | FYNPIK3CA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012020215-A1 | AMINO- IMIDAZOLOTHIADIAZOLES FOR USE AS PROTEIN OR LIPID KINASE INHIBITORS | CENTRO NACIONAL DE INVESTIGACIONES ONCOLÓGICAS (CNIO) (ES) | 2012-02-16 | — | — | WO | disclosed |