SCHEMBL625761

SCHEMBL625761

O=c1[nH]c2cc(Cl)ccc2c(=O)o1

nearest known ligand 0.62

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
LMNA P02545 4/20 0.62
BLM P54132 2/20 0.62
CYP1A2 P05177 1/20 0.62
ADRA2A P08913 1/20 0.62
TSHR P16473 1/20 0.62
NOS3 P29474 1/20 0.62
NOS1 P29475 1/20 0.62
NOS2 P35228 1/20 0.62
THPO P40225 1/20 0.62
NPSR1 Q6W5P4 1/20 0.62
F2 P00734 1/20 0.56
CFD P00746 1/20 0.56
PARP1 P09874 1/20 0.53
TP53 P04637 1/20 0.51
SMN1; SMN2 Q16637 1/20 0.51
ALDH1A1 P00352 2/20 0.50
CA9 Q16790 2/20 0.47
CA12 O43570 1/20 0.47
DAO P14920 1/20 0.47
HPGD P15428 2/20 0.46

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL30557808 1.00 LMNA (0.62) LMNABLMCYP1A2ADRA2ATSHR
SCHEMBL62706 0.85 LMNA (0.58) LMNABLMCYP1A2ADRA2ATSHR
SCHEMBL30908765 0.85 LMNA (0.58) LMNABLMCYP1A2ADRA2ATSHR
SCHEMBL1202554 0.78 F2 (0.56) LMNAF2CFDPARP1ALDH1A1
SCHEMBL31607092 0.78 F2 (0.56) F2CFDPARP1SMN1; SMN2ALDH1A1
SCHEMBL31607095 0.78 F2 (0.56) F2CFDPARP1SMN1; SMN2ALDH1A1
SCHEMBL12324556 0.78 F2 (0.56) LMNABLMCYP1A2ADRA2ATSHR
SCHEMBL3435898 0.78 NOS1 (0.62) LMNANOS3NOS1NOS2F2
SCHEMBL7422358 0.78 F2 (0.56) LMNABLMCYP1A2ADRA2ATSHR
SCHEMBL30549739 0.78 F2 (0.56) LMNAF2CFDHPGD

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 204 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-118727475-B Room temperature salt-free rapid reactive dyeing and recycling method suitable for cellulose fibers 绍兴劲草化工有限公司 2025-04-29 CN claimed
CN-119098205-A Nitrogen-doped porous carbon-loaded cobalt monoatomic catalyst and preparation method and application thereof 南京理工大学 2024-12-10 CN claimed
CN-118727475-A Room temperature salt-free rapid reactive dyeing and recycling method suitable for cellulose fibers 绍兴劲草化工有限公司 2024-10-01 CN claimed
CN-117603144-A Synthesis method of polysubstituted quinazolinone 常熟泓德生物科技有限公司 2024-02-27 CN claimed
EP-3947667-A1 MODIFIED CLEAVASES, USES THEREOF AND RELATED KITS Encodia, Inc. (US) 2022-02-09 EP claimed
CN-113993997-A Modified cleaving enzymes, uses thereof and related kits ENCODIA 公司 2022-01-28 CN claimed
CN-110372611-B Method for selectively synthesizing polysubstituted dihydro quinazolinone or quinazolinone 常熟理工学院 2021-05-04 CN claimed
WO-2020198264-A1 MODIFIED CLEAVASES, USES THEREOF AND RELATED KITS Encodia, Inc. (US) 2020-10-01 WO claimed
CN-110372611-A A kind of method of the polysubstituted dihydroquinazoline ketone of selectivity synthesis or quinazolinone 常熟理工学院 2019-10-25 CN claimed
JP-5209132-A None JP disclosed
EP-4727923-A1 TETRAHYDROACRIDINONE ANALOGUES FOR TREATMENT AND PREVENTION OF MALARIA University of Georgia Research Foundation, Inc. (US) 2026-04-22 EP disclosed
EP-4730479-A2 FLAME-RETARDANT NON-AQUEOUS ELECTROLYTIC SOLUTION AND SECONDARY BATTERY USING SAME Kyoto University (JP) 2026-04-22 EP disclosed
US-20260098012-A1 TETRAHYDROACRIDINONE ANALOGUES FOR TREATMENT AND PREVENTION OF MALARIA UNIV GEORGIA (US) 2026-04-09 US disclosed
US-12564583-B2 Small molecules against cereblon to enhance effector T cell function Lee Moffitt Cancer Center and Research Institute, Inc. (US) 2026-03-03 US disclosed
US-4710502-A THROMBOXANE SYNTHETASE INHIBITORS AMERICAN CYANAMID COMPANY (US) 1987-12-01 US disclosed
US-4684654-A THROMBOXANE SYNTHETASE INHIBITORS, HYPOTENSIVES AMERICAN CYANAMID COMPANY (US) 1987-08-04 US disclosed
EP-0218999-A2 New quinazoline derivatives, process for their production and pharmaceutical compositions comprising them FUJISAWA PHARMACEUTICAL CO., LTD. (JP) 1987-04-22 EP disclosed
US-4659718-A VASODILATION THE BOOTS COMPANY PLC (GB) 1987-04-21 US disclosed
EP-0135367-A1 Therapeutic agents The Boots Company PLC (GB) 1985-03-27 EP disclosed
US-3984562-A TREATING ANXIETY AMERICAN CYANAMID COMPANY (US) 1976-10-05 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20260098012-A1 TETRAHYDROACRIDINONE ANALOGUES FOR TREATMENT AND PREVENTION OF MALARIA CD47, SLC11A2, G6PD LMNA 297/4885BLM 4619/4885CYP1A2 1169/4885
US-12564583-B2 Small molecules against cereblon to enhance effector T cell function CRBN, CD4, ICOS LMNA 2916/4885BLM 4143/4885CYP1A2 4377/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.