Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AKT2 | P31751 | 2/20 | 0.59 |
| ▸ | AKT1 | P31749 | 1/20 | 0.59 |
| ▸ | PRMT5 | O14744 | 3/20 | 0.59 |
| ▸ | ROCK2 | O75116 | 3/20 | 0.56 |
| ▸ | RAB9A | P51151 | 2/20 | 0.52 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.52 |
| ▸ | MEN1 | O00255 | 1/20 | 0.52 |
| ▸ | NPC1 | O15118 | 1/20 | 0.52 |
| ▸ | POLB | P06746 | 1/20 | 0.52 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.52 |
| ▸ | ENPP3 | O14638 | 1/20 | 0.52 |
| ▸ | ENPP1 | P22413 | 1/20 | 0.52 |
| ▸ | LMNA | P02545 | 1/20 | 0.51 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.51 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.51 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.51 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.51 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.51 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.51 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4051954 | 0.83 | AKT1 (0.54) | AKT2AKT1PRMT5ROCK2MAPT | |
| SCHEMBL197017 | 0.82 | LMNA (0.72) | RAB9ASMN1; SMN2MEN1NPC1POLB | |
| SCHEMBL9033160 | 0.81 | LMNA (0.50) | AKT2AKT1PRMT5RAB9ASMN1; SMN2 | |
| SCHEMBL11870228 | 0.81 | LMNA (0.50) | AKT2AKT1PRMT5RAB9ASMN1; SMN2 | |
| SCHEMBL23483029 | 0.80 | LMNA (0.69) | RAB9ASMN1; SMN2MEN1NPC1POLB | |
| SCHEMBL1096817 | 0.80 | LMNA (0.69) | RAB9ASMN1; SMN2MEN1NPC1POLB | |
| SCHEMBL16872766 | 0.78 | AKT2 (0.95) | AKT2AKT1ROCK2 | |
| SCHEMBL13373563 | 0.78 | LMNA (0.50) | AKT2AKT1PRMT5RAB9ASMN1; SMN2 | |
| SCHEMBL6059308 | 0.77 | LMNA (0.64) | RAB9ASMN1; SMN2MEN1NPC1POLB | |
| SCHEMBL3722814 | 0.77 | ROCK2 (0.60) | AKT2AKT1PRMT5ROCK2MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2005000309-A2 | CHEMICAL COMPOUNDS | IONIX PHARMACEUTICALS LIMITED (GB) | 2005-01-06 | — | — | WO | disclosed |