Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIM1 | P11309 | 12/20 | 0.55 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.52 |
| ▸ | DYRK1A | Q13627 | 5/20 | 0.47 |
| ▸ | DGAT2 | Q96PD7 | 1/20 | 0.46 |
| ▸ | PDE4A | P27815 | 1/20 | 0.45 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.45 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.45 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.45 |
| ▸ | GAK | O14976 | 1/20 | 0.44 |
| ▸ | STK10 | O94804 | 1/20 | 0.44 |
| ▸ | YES1 | P07947 | 1/20 | 0.44 |
| ▸ | RET | P07949 | 1/20 | 0.44 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.44 |
| ▸ | CSNK2A2 | P19784 | 1/20 | 0.44 |
| ▸ | FLT3 | P36888 | 1/20 | 0.44 |
| ▸ | ACVR1 | Q04771 | 1/20 | 0.44 |
| ▸ | PKN1 | Q16512 | 1/20 | 0.44 |
| ▸ | PIM3 | Q86V86 | 1/20 | 0.44 |
| ▸ | HASPIN | Q8TF76 | 1/20 | 0.44 |
| ▸ | SIK2 | Q9H0K1 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL623998 | 0.89 | PIM1 (0.51) | PIM1DYRK1ADGAT2KCNH2GAK | |
| SCHEMBL624449 | 0.87 | PIM1 (0.69) | PIM1DYRK1AKCNH2PIM2 | |
| SCHEMBL625777 | 0.84 | MAPT (0.56) | NOTUMDGAT2 | |
| SCHEMBL623131 | 0.83 | PIM1 (0.61) | PIM1DYRK1AKCNH2GAKSTK10 | |
| SCHEMBL624016 | 0.82 | PIM1 (0.49) | PIM1KCNH2GAKSTK10YES1 | |
| SCHEMBL624481 | 0.79 | PIM1 (0.56) | PIM1DYRK1AKCNH2GAKSTK10 | |
| SCHEMBL623866 | 0.78 | DYRK1A (0.48) | PIM1DYRK1AKCNH2 | |
| SCHEMBL625222 | 0.77 | PIK3CA (0.48) | KCNH2 | |
| SCHEMBL625741 | 0.76 | PIM1 (0.45) | PIM1DYRK1A | |
| SCHEMBL626627 | 0.76 | PIM1 (0.45) | PIM1DYRK1AKCNH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012020217-A1 | AMINO- IMIDAZOLOTHIADIAZOLES FOR USE AS PROTEIN OR LIPID KINASE INHIBITORS | CENTRO NACIONAL DE INVESTIGACIONES ONCOLÓGICAS (CNIO) (ES) | 2012-02-16 | — | — | WO | disclosed |