Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIM1 | P11309 | 13/20 | 0.51 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.45 |
| ▸ | MAPT | P10636 | 2/20 | 0.45 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.45 |
| ▸ | HPGD | P15428 | 1/20 | 0.45 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.45 |
| ▸ | CASP1 | P29466 | 1/20 | 0.45 |
| ▸ | CASP7 | P55210 | 1/20 | 0.45 |
| ▸ | FLT3 | P36888 | 2/20 | 0.44 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.44 |
| ▸ | PIM3 | Q86V86 | 2/20 | 0.44 |
| ▸ | PIM2 | Q9P1W9 | 2/20 | 0.44 |
| ▸ | GAK | O14976 | 1/20 | 0.44 |
| ▸ | STK10 | O94804 | 1/20 | 0.44 |
| ▸ | YES1 | P07947 | 1/20 | 0.44 |
| ▸ | RET | P07949 | 1/20 | 0.44 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.44 |
| ▸ | CSNK2A2 | P19784 | 1/20 | 0.44 |
| ▸ | ACVR1 | Q04771 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL625776 | 0.89 | PIM1 (0.55) | PIM1FLT3KCNH2PIM3PIM2 | |
| SCHEMBL623999 | 0.85 | MAPT (0.55) | MAPTTP53 | |
| SCHEMBL624449 | 0.83 | PIM1 (0.69) | PIM1KCNH2PIM2DYRK1A | |
| SCHEMBL624633 | 0.80 | PIK3CA (0.47) | ALDH1A1KDM4EMAPTHSD17B10HPGD | |
| SCHEMBL624016 | 0.80 | PIM1 (0.49) | PIM1FLT3KCNH2PIM3PIM2 | |
| SCHEMBL623131 | 0.79 | PIM1 (0.61) | PIM1FLT3KCNH2PIM3PIM2 | |
| SCHEMBL628099 | 0.77 | ALDH1A1 (0.49) | ALDH1A1KDM4EMAPTHSD17B10HPGD | |
| SCHEMBL624481 | 0.77 | PIM1 (0.56) | PIM1FLT3KCNH2PIM3PIM2 | |
| SCHEMBL623866 | 0.74 | DYRK1A (0.48) | PIM1KCNH2DYRK1A | |
| SCHEMBL625034 | 0.74 | PIM1 (0.54) | PIM1FLT3KCNH2PIM3PIM2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012020217-A1 | AMINO- IMIDAZOLOTHIADIAZOLES FOR USE AS PROTEIN OR LIPID KINASE INHIBITORS | CENTRO NACIONAL DE INVESTIGACIONES ONCOLÓGICAS (CNIO) (ES) | 2012-02-16 | — | — | WO | disclosed |