SCHEMBL6257900

SCHEMBL6257900

CC[Si]1(CC)C(c2ccc(C[Si](C)(C)C)nc2)=C(c2ccccc2)C(c2ccccc2)=C1c1ccc(C[Si](C)(C)C)nc1

nearest known ligand 0.35

Predicted protein targets (top 8)

geneUniProtsupporting neighboursconfidence
LIPG Q9Y5X9 1/20 0.30
KDM4E B2RXH2 1/20 0.30
NPC1 O15118 1/20 0.30
ALDH1A1 P00352 1/20 0.30
TP53 P04637 1/20 0.30
HPGD P15428 1/20 0.30
RAB9A P51151 1/20 0.30
SMN1; SMN2 Q16637 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL6254411 0.88
SCHEMBL7117261 0.86 LIPG (0.31) LIPGNPC1RAB9ASMN1; SMN2
SCHEMBL6256045 0.80 NPC1 (0.31) KDM4ENPC1ALDH1A1TP53HPGD
SCHEMBL6254611 0.80 HPGDS (0.45) NPC1TP53RAB9ASMN1; SMN2
SCHEMBL6256305 0.80 HPGDS (0.38) NPC1HPGDRAB9ASMN1; SMN2
SCHEMBL6257555 0.79
SCHEMBL6256372 0.76 PTGS2 (0.31) ALDH1A1
SCHEMBL7119607 0.75 TRPV3 (0.33) RAB9A
SCHEMBL10018833 0.75 SMN1; SMN2 (0.38) KDM4EALDH1A1HPGDRAB9ASMN1; SMN2
SCHEMBL6253373 0.75 ALDH1A1 (0.35) ALDH1A1TP53HPGDSMN1; SMN2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1143538-B1 Organic electroluminescent element containing a silacyclopentadiene derivative CHISSO CORP (JP) 2005-09-14 EP disclosed
EP-0754691-B1 Silacyclopentadiene derivatives and an organic electroluminescent element obtained by using the silacyclopentadiene derivative CHISSO CORP (JP) 2003-11-19 EP disclosed
EP-1143538-A1 Silacyclopentadiene derivatives and an organic electroluminescent element obtained by using the silacyclopentadiene derivative Chisso Corporation (JP) 2001-10-10 EP disclosed
US-6051319-A Silacyclopentadiene derivatives and an organic electroluminescent element obtained by using the silacyclopentadiene derivative CHISSO CORPORATION (JP) 2000-04-18 US disclosed
US-5986121-A Silacyclopentadiene derivatives and an organic electroluminescent element obtained by using the silacyclopentadiene derivative CHISSO CORPORATION (JP) 1999-11-16 US disclosed
EP-0754691-A2 Silacyclopentadiene derivatives and an organic electroluminescent element obtained by using the silacyclopentadiene derivative CHISSO CORPORATION (JP) 1997-01-22 EP disclosed