SCHEMBL625828

SCHEMBL625828

Nc1nc(N)c2ncn([C@@H]3O[C@H](COP(=O)(O)OP(=O)(O)OP(=O)(O)O)[C@@H](O)[C@H]3O)c2n1

nearest known ligand 0.79

Predicted protein targets (top 19)

geneUniProtsupporting neighboursconfidence
P2RY1 P47900 8/20 0.79
P2RX3 P56373 3/20 0.79
ENPP1 P22413 2/20 0.79
P2RX1 P51575 2/20 0.79
P2RX4 Q99571 2/20 0.79
P2RY11 Q96G91 2/20 0.79
P2RY6 Q15077 1/20 0.79
P2RY12 Q9H244 1/20 0.77
NT5E P21589 1/20 0.76
RNASEL Q05823 2/20 0.74
P2RY2 P41231 2/20 0.73
SRC P12931 1/20 0.73
P2RX2 Q9UBL9 1/20 0.73
ALDH1A1 P00352 1/20 0.73
SMN1; SMN2 Q16637 1/20 0.73
IMPDH2 P12268 1/20 0.72
IMPDH1 P20839 1/20 0.72
GPR17 Q13304 2/20 0.72
CA5A P35218 1/20 0.69

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL29471291 1.00 P2RY1 (0.79) P2RY1P2RX3ENPP1P2RX1P2RX4
SCHEMBL13857854 1.00 P2RY1 (0.79) P2RY1P2RX3ENPP1P2RX1P2RX4
SCHEMBL18269547 1.00 P2RY1 (0.79) P2RY1P2RX3ENPP1P2RX1P2RX4
SCHEMBL12932283 1.00 P2RY1 (0.79) P2RY1P2RX3ENPP1P2RX1P2RX4
SCHEMBL17211052 1.00 P2RY1 (0.79) P2RY1P2RX3ENPP1P2RX1P2RX4
SCHEMBL3502237 1.00 P2RY1 (0.79) P2RY1P2RX3ENPP1P2RX1P2RX4
SCHEMBL16081048 0.93 P2RX3 (0.79) P2RY1P2RX3ENPP1P2RX1P2RX4
SCHEMBL12932310 0.93 P2RY1 (0.71) P2RY1P2RX3ENPP1P2RX1P2RX4
SCHEMBL15794408 0.93 P2RY1 (0.79) P2RY1P2RX3ENPP1P2RX1P2RX4
SCHEMBL22224584 0.92 P2RY1 (0.68) P2RY1P2RX3ENPP1P2RX1P2RX4

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1235 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-12460204-B2 Artificial nucleic acid molecules for improved protein or peptide expression CureVac SE (DE) 2025-11-04 US claimed
US-20250210148-A1 METHOD OF PRODUCING DATA-ENCODED NUCLEIC ACID AND NUCLEIC ACID PRODUCED BY THE SAME SAMSUNG ELECTRONICS CO., LTD. (KR) 2025-06-26 US claimed
CN-119375375-A Method for detecting nucleotide, cap analogue and nucleic acid in vitro transcription product 楷拓生物科技(苏州)有限公司 2025-01-28 CN claimed
US-20240415958-A1 MESSENGER RNA THERAPY FOR TREATMENT OF ARTICULAR DISEASE TRANSLATE BIO INC (US) 2024-12-19 US claimed
US-11998601-B2 Messenger RNA therapy for treatment of articular disease TRANSLATE BIO, INC. (US) 2024-06-04 US claimed
US-20220372158-A1 RNA-CODED ANTIBODY CUREVAC AG (DE) 2022-11-24 US claimed
EP-3115064-B1 RNA-CODED ANTIBODY CUREVAC AG (DE) 2021-11-24 EP claimed
US-11110156-B2 Nucleic acid comprising or coding for a histone stem-loop and a poly(a) sequence or a polyadenylation signal for increasing the expression of an encoded tumour antigen CUREVAC AG (DE) 2021-09-07 US claimed
US-20210060175-A1 METHODS OF IMMUNOSTIMULATION WITH COMPLEXES OF RNA AND CATIONIC CARRIERS CUREVAC AG (DE) 2021-03-04 US claimed
US-20210060181-A1 NUCLEIC ACID COMPRISING OR CODING FOR A HISTONE STEM-LOOP AND A POLY(A) SEQUENCE OR A POLYADENYLATION SIGNAL FOR INCREASING THE EXPRESSION OF AN ENCODED THERAPEUTIC PROTEIN CUREVAC AG (DE) 2021-03-04 US claimed
EP-2451980-B1 CHEMICALLY MODIFIED LIGASE COFACTORS, DONORS AND ACCEPTORS TRILINK BIOTECHNOLOGIES (US) 2014-05-21 EP claimed
US-8728725-B2 Chemically modified ligase cofactors, donors and acceptors TRILINK BIOTECHNOLOGIES (US) 2014-05-20 US claimed
US-20130195867-A1 RNA-CODED ANTIBODY CUREVAC GMBH (DE) 2013-08-01 US claimed
US-20110008788-A1 CHEMICALLY MODIFIED LIGASE COFACTORS, DONORS AND ACCEPTORS TriLink Bio Technologies 2011-01-13 US claimed
US-20100189729-A1 RNA-CODED ANTIBODY CURVAC GMBH (DE) 2010-07-29 US claimed
US-20100047261-A1 BASE-MODIFIED RNA FOR INCREASING THE EXPRESSION OF A PROTEIN CUREVAC GMBH (DE) 2010-02-25 US claimed
EP-2083851-A2 (BASE-)MODIFIED RNA FOR INCREASING THE EXPRESSION OF A PROTEIN Curevac GmbH (DE) 2009-08-05 EP claimed
WO-2008052770-A2 (BASE-)MODIFIED RNA FOR INCREASING THE EXPRESSION OF A PROTEIN CUREVAC GMBH (DE) 2008-05-08 WO claimed
EP-1624059-A2 Method of producing nucleic acid molecules with reduced secondary structure Agilent Technologies, Inc. (US) 2006-02-08 EP claimed
US-20040086880-A1 Method of producing nucleic acid molecules with reduced secondary structure AGILENT TECHNOLOGIES, INC. 2004-05-06 US claimed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (6 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20210060181-A1 NUCLEIC ACID COMPRISING OR CODING FOR A HISTONE STEM-LOOP AND A POLY(A) SEQUENCE OR A POLYADENYLATION SIGNAL FOR INCREASING THE EXPRESSION OF AN ENCODED THERAPEUTIC PROTEIN HNRNPH3, CPSF6, HNRNPL P2RY1 2048/4885P2RX3 1904/4885ENPP1 2122/4885
US-12460204-B2 Artificial nucleic acid molecules for improved protein or peptide expression RNMT, NSUN3, RNGTT P2RY1 2831/4885P2RX3 2043/4885ENPP1 2442/4885
US-20100047261-A1 BASE-MODIFIED RNA FOR INCREASING THE EXPRESSION OF A PROTEIN RNMT, RNASE1, NSUN3 P2RY1 4557/4885P2RX3 4449/4885ENPP1 905/4885
US-20240415958-A1 MESSENGER RNA THERAPY FOR TREATMENT OF ARTICULAR DISEASE NSUN3, RNMT, TRDMT1 P2RY1 3509/4885P2RX3 2826/4885ENPP1 1221/4885
US-11998601-B2 Messenger RNA therapy for treatment of articular disease NSUN3, RNMT, TRDMT1 P2RY1 3509/4885P2RX3 2826/4885ENPP1 1221/4885
US-11110156-B2 Nucleic acid comprising or coding for a histone stem-loop and a poly(a) sequence or a polyadenylation signal for increasing the expression of an encoded tumour antigen HNRNPH3, HNRNPL, CPSF6 P2RY1 1808/4885P2RX3 1525/4885ENPP1 1975/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.