Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | METAP2 | P50579 | 1/20 | 0.39 |
| ▸ | PGR | P06401 | 2/20 | 0.38 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.34 |
| ▸ | PDE2A | O00408 | 2/20 | 0.33 |
| ▸ | PDE3B | Q13370 | 2/20 | 0.33 |
| ▸ | PDE3A | Q14432 | 2/20 | 0.33 |
| ▸ | GRM2 | Q14416 | 5/20 | 0.33 |
| ▸ | DAO | P14920 | 1/20 | 0.32 |
| ▸ | MAOB | P27338 | 1/20 | 0.31 |
| ▸ | JAK2 | O60674 | 1/20 | 0.31 |
| ▸ | PIM1 | P11309 | 1/20 | 0.31 |
| ▸ | PIM3 | Q86V86 | 1/20 | 0.31 |
| ▸ | PIM2 | Q9P1W9 | 1/20 | 0.31 |
| ▸ | MEN1 | O00255 | 1/20 | 0.31 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL625475 | 0.81 | PGR (0.57) | PGRRXFP1LMNAMAPTMAOB | |
| SCHEMBL625493 | 0.77 | PDE3B (0.43) | METAP2RXFP1LMNAPDE3BPDE3A | |
| SCHEMBL625884 | 0.76 | PGR (0.40) | PGRLMNAGRM2DAO | |
| SCHEMBL625682 | 0.75 | GRM2 (0.42) | PGRLMNAGRM2DAO | |
| SCHEMBL627637 | 0.74 | PDE2A (0.44) | LMNAPDE2APDE3BPDE3A | |
| SCHEMBL627105 | 0.73 | METAP2 (0.41) | METAP2RXFP1LMNAMAPTPDE2A | |
| SCHEMBL625578 | 0.73 | CHEK1 (0.36) | PGRRXFP1LMNAPDE3BPDE3A | |
| SCHEMBL626022 | 0.71 | CYP11B1 (0.33) | RXFP1 | |
| SCHEMBL624871 | 0.71 | CSNK2A2 (0.36) | RXFP1LMNAMAPTPDE2APDE3B | |
| SCHEMBL625999 | 0.69 | BRD4 (0.35) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2603079-A1 | POSITIVE ALLOSTERIC MODULATORS OF MGLUR2 | Merck Sharp & Dohme Corp. (US) | 2013-06-19 | — | — | EP | disclosed |
| WO-2012021382-A1 | POSITIVE ALLOSTERIC MODULATORS OF MGLUR2 | MERCK SHARP & DOHME CORP. (US) | 2012-02-16 | — | — | WO | disclosed |