SCHEMBL6263155

SCHEMBL6263155

CC1(C)OCC(COn2c(N)nc3nc[nH]c3c2=O)O1

nearest known ligand 0.37

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CA2 P00918 1/20 0.37
ALDH1A1 P00352 2/20 0.36
NPSR1 Q6W5P4 1/20 0.36
CCNK O75909 1/20 0.34
CDK12 Q9NYV4 1/20 0.34
CDK2 P24941 8/20 0.34
CDK1 P06493 7/20 0.34
CCNB1 P14635 7/20 0.34
CCNA2 P20248 7/20 0.34
CCNA1 P78396 7/20 0.34
MGMT P16455 2/20 0.33
MAPK14 Q16539 3/20 0.33
CCNB2 O95067 2/20 0.32
CCNB3 Q8WWL7 2/20 0.32
MAPK3 P27361 1/20 0.32
CLK1 P49759 1/20 0.32
CDK5 Q00535 1/20 0.32
PIN1 Q13526 1/20 0.32
MAP3K5 Q99683 1/20 0.32
PNP P00491 1/20 0.32

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL6268673 0.87 ALDH1A1 (0.39) ALDH1A1CDK2CDK1CCNB1CCNA2
SCHEMBL7981045 0.75 CDK1 (0.57) CDK2CDK1CCNB1CCNA2CCNA1
SCHEMBL8075242 0.75 CDK1 (0.57) CDK2CDK1CCNB1CCNA2CCNA1
SCHEMBL4428837 0.75 CDK1 (0.57) CDK2CDK1CCNB1CCNA2CCNA1
SCHEMBL27775483 0.75 CDK1 (0.43) CDK2CDK1CCNB1CCNA2CCNA1
SCHEMBL8072893 0.73 CDK1 (0.48) CDK2CDK1CCNB1CCNA2CCNA1
SCHEMBL27503508 0.73 CDK1 (0.50) CDK2CDK1CCNB1CCNA2CCNA1
SCHEMBL28026664 0.71 PNP (0.45) ALDH1A1CDK2CDK1CCNB1CCNA2
SCHEMBL7702158 0.68 PIN1 (0.53) ALDH1A1CDK2CDK1CCNB1CCNA2
SCHEMBL8068291 0.67 CA2 (0.37) CA2ALDH1A1NPSR1CCNKCDK12

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1017394-B1 CYCLIN DEPENDENT KINASE INHIBITING PURINE DERIVATIVES CANCER REC TECH LTD (GB) 2005-12-07 EP claimed
US-6303618-B1 ADMINISTERING PURINE COMPOUND WHICH INHIBITS CYCLIC DEPENDENT KINASE ACTIVITY FOR THERAPY OF TUMOR OR OTHER CELL PROLIFERATION DISORDER CANCER RESEARCH CAMPAIGN TECHNOLOGY LIMITED (GB) 2001-10-16 US claimed
EP-1017394-B1 CYCLIN DEPENDENT KINASE INHIBITING PURINE DERIVATIVES CANCER REC TECH LTD (GB) 2005-12-07 EP disclosed
EP-1066266-B1 CYCLIN DEPENDENT KINASE INHIBITORS CANCER REC TECH LTD (GB) 2005-11-09 EP disclosed
US-6677345-B1 PYRMIDINE DERIVATIVE ANTITUMOR AND ANTIPROLIFERATIVE AGENTS CANCER RESEARCH CAMPAIGN TECHNOLOGY LIMITED (GB) 2004-01-13 US disclosed
US-6303618-B1 ADMINISTERING PURINE COMPOUND WHICH INHIBITS CYCLIC DEPENDENT KINASE ACTIVITY FOR THERAPY OF TUMOR OR OTHER CELL PROLIFERATION DISORDER CANCER RESEARCH CAMPAIGN TECHNOLOGY LIMITED (GB) 2001-10-16 US disclosed