Sugi Predict

Sugi Predict / Compounds / SCHEMBL626424

SCHEMBL626424

SCHEMBL626424

NCCN1C(=O)c2cccc3cccc(c23)C1=O

nearest known ligand 1.00 ✓ in ChEMBL — recovers established targets

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ HEXA P06865 6/20 1.00
▸ HEXB P07686 6/20 1.00
▸ OGA O60502 1/20 0.67
▸ LCK P06239 1/20 0.66
▸ KDM4E B2RXH2 3/20 0.63
▸ ALDH1A1 P00352 3/20 0.63
▸ MAPT P10636 2/20 0.63
▸ SMN1; SMN2 Q16637 2/20 0.63
▸ GAA P10253 1/20 0.63
▸ RAB9A P51151 1/20 0.63
▸ CYP1B1 Q16678 1/20 0.62
▸ SIRT1 Q96EB6 3/20 0.61
▸ KMT2A Q03164 3/20 0.59
▸ MEN1 O00255 2/20 0.59
▸ POLB P06746 2/20 0.59
▸ NR1I2 O75469 1/20 0.59
▸ AHR P35869 1/20 0.59
▸ RAD52 P43351 1/20 0.59
▸ RCE1 Q9Y256 1/20 0.59
▸ HSD17B10 Q99714 2/20 0.57

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Hydrochloric Acid SCHEMBL28259369 0.98 HEXA (0.96) HEXAHEXBOGALCKKDM4E
Naphthalimidopropylamine SCHEMBL12502105 0.89 HEXA (1.00) HEXAHEXBOGALCKKDM4E
SCHEMBL5094701 0.88 HEXA (1.00) HEXAHEXBOGALCKKDM4E
SCHEMBL9290383 0.88 HEXA (0.78) HEXAHEXBOGALCKKDM4E
SCHEMBL6601488 0.86 HEXA (0.97) HEXAHEXBOGALCKKDM4E
SCHEMBL2365312 0.86 HEXA (0.74) HEXAHEXBOGALCKKDM4E
SCHEMBL9626265 0.85 HEXA (0.83) HEXAHEXBOGAKDM4EALDH1A1
SCHEMBL13207607 0.85 HEXA (0.73) HEXAHEXBOGALCKKDM4E
SCHEMBL9625535 0.83 HEXA (0.81) HEXAHEXBOGAKDM4EALDH1A1
SCHEMBL9625518 0.83 HEXA (0.81) HEXAHEXBOGAKDM4EALDH1A1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 34 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-109554004-B Pigment dispersants and their use 江苏丽王科技股份有限公司 2024-02-20 — — CN claimed
CN-107698571-B Naphthalimide-coumarin DNA targeting double-intercalator, synthesis and application thereof 大连理工大学 2020-07-14 — — CN claimed
CN-109554004-A Pigment dispersing agent and application thereof 江苏丽王科技股份有限公司 2019-04-02 — — CN claimed
US-20240287261-A1 METHOD FOR PRODUCING POLYMERIC NANOFIBER AGGREGATE, POLYMERIC NANOFIBER AGGREGATE, UNIAXIALLY ORIENTED POLYMERIC NANOFIBER AGGREGATE SUBSTRATE, AND LASER DESORPTION/IONIZATION MASS SPECTROMETRY SUBSTRATE KABUSHIKI KAISHA TOYOTA CHUO KENKYUSHO (JP) 2024-08-29 — — US disclosed
CN-109554004-B Pigment dispersants and their use 江苏丽王科技股份有限公司 2024-02-20 — — CN disclosed
CN-108329263-B 1, 8-naphthalimide amide compound and application thereof 青岛科技大学 2020-12-15 — — CN disclosed
CN-105934510-B Photoactivators 宝洁公司 2020-07-24 — — CN disclosed
CN-107698571-B Naphthalimide-coumarin DNA targeting double-intercalator, synthesis and application thereof 大连理工大学 2020-07-14 — — CN disclosed
CN-109554004-A Pigment dispersing agent and application thereof 江苏丽王科技股份有限公司 2019-04-02 — — CN disclosed
CN-108865116-A A kind of film and preparation method thereof with room temperature phosphorimetry 福建师范大学 2018-11-23 — — CN disclosed
EP-1957507-B1 ANTIBACTERIAL 4,5-SUBSTITUTED AMINOGLYCOSIDE ANALOGS HAVING MULTIPLE SUBSTITUENTS IONIS PHARMACEUTICALS INC (US) 2018-10-24 — — EP disclosed
US-7893039-B2 Antibacterial 4,5-substituted aminoglycoside analogs having multiple substituents ISIS PHARMACEUTICALS, INC. (US) 2011-02-22 — — US disclosed
US-20080293649-A1 ANTIBACTERIAL 4,5-SUBSTITUTED AMINOGLYCOSIDE ANALOGS HAVING MULTIPLE SUBSTITUENTS ISIS PHARMACEUTICALS, INC. (US) 2008-11-27 — — US disclosed
US-20080045468-A1 ANTIMICROBIAL 2-DEOXYSTREPTAMINE COMPOUNDS ISIS PHARMACEUTICALS, INC. (US) 2008-02-21 — — US disclosed
WO-2007064345-A9 HETEROCYCLIC-SUBSTITUTED BIS-1,8 NAPHTHALIMIDE COMPOUNDS, ANTIBODY DRUG CONJUGATES, AND METHODS OF USE GENENTECH INC (US) 2007-07-12 — — WO disclosed
US-20070134243-A1 Antibody drug conjugates and methods GENENTECH, INC. 2007-06-14 — — US disclosed
US-7192967-B1 Cyclic imide-substituted pyridylalkane, alkene, alkine carboxamides useful as cytostatic and immunosuppressive agents ASTELLAS PHARMA GMBH (DE) 2007-03-20 — — US disclosed
EP-1042315-B1 CYCLIC IMIDE-SUBSTITUTED PYRIDYLALKANE, ALKENE, AND ALKINE CARBOXAMIDES USEFUL AS CYTOSTATIC AND IMMUNOSUPPRESSIVE AGENTS KLINGE CO CHEM PHARM FAB (DE) 2004-04-14 — — EP disclosed
EP-1042315-A1 CYCLIC IMIDE-SUBSTITUTED PYRIDYLALKANE, ALKENE, AND ALKINE CARBOXAMIDES USEFUL AS CYTOSTATIC AND IMMUNOSUPPRESSIVE AGENTS Klinge Pharma GmbH (DE) 2000-10-11 — — EP disclosed
WO-1999031087-A1 CYCLIC IMIDE-SUBSTITUTED PYRIDYLALKANE, ALKENE AND ALKINE CARBOXAMIDES USEFUL AS CYTOSTATIC AND IMMUNOSUPPRESSIVE AGENTS KLINGE PHARMA GMBH (DE) 1999-06-24 — — WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20080293649-A1 ANTIBACTERIAL 4,5-SUBSTITUTED AMINOGLYCOSIDE ANALOGS HAVING MULTIPLE SUBSTITUENTS ALG8, MRPL21, AADAC HEXA 829/4885HEXB 1156/4885OGA 15/4885
US-20080045468-A1 ANTIMICROBIAL 2-DEOXYSTREPTAMINE COMPOUNDS MTAP, UNG, PNMT HEXA 944/4885HEXB 1478/4885OGA 414/4885
US-20070134243-A1 Antibody drug conjugates and methods BOD1L1, MKI67, CCNI HEXA 3422/4885HEXB 3477/4885OGA 2564/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.