Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HEXA | P06865 | 6/20 | 0.74 |
| ▸ | HEXB | P07686 | 6/20 | 0.74 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.71 |
| ▸ | FTO | Q9C0B1 | 1/20 | 0.71 |
| ▸ | MEN1 | O00255 | 2/20 | 0.70 |
| ▸ | POLB | P06746 | 2/20 | 0.70 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.70 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.70 |
| ▸ | MAPT | P10636 | 2/20 | 0.70 |
| ▸ | RAB9A | P51151 | 2/20 | 0.70 |
| ▸ | AHR | P35869 | 1/20 | 0.70 |
| ▸ | RECQL | P46063 | 1/20 | 0.70 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.68 |
| ▸ | TNNI3 | P19429 | 1/20 | 0.68 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.68 |
| ▸ | STAT6 | P42226 | 1/20 | 0.68 |
| ▸ | TNNT2 | P45379 | 1/20 | 0.68 |
| ▸ | TNNC1 | P63316 | 1/20 | 0.68 |
| ▸ | MPO | P05164 | 1/20 | 0.66 |
| ▸ | LCK | P06239 | 2/20 | 0.59 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28781804 | 0.88 | HEXA (0.57) | HEXAHEXBCYP2D6FTOMEN1 | |
| SCHEMBL626424 | 0.86 | HEXA (1.00) | HEXAHEXBMEN1POLBKMT2A | |
| SCHEMBL9502888 | 0.86 | HEXA (0.73) | HEXAHEXBCYP2D6FTOMEN1 | |
| SCHEMBL8670307 | 0.86 | CYP2D6 (0.61) | HEXAHEXBCYP2D6FTOMEN1 | |
| SCHEMBL8670304 | 0.85 | CYP2D6 (0.64) | HEXAHEXBCYP2D6FTOMEN1 | |
| SCHEMBL9092319 | 0.85 | SIRT1 (0.63) | HEXAHEXBCYP2D6FTOMEN1 | |
| Hydrochloric Acid SCHEMBL28259369 | 0.84 | HEXA (0.96) | HEXAHEXBMEN1POLBKMT2A | |
| SCHEMBL9091823 | 0.84 | SIRT1 (0.65) | HEXAHEXBCYP2D6FTOMEN1 | |
| SCHEMBL19872905 | 0.83 | POLB (0.70) | HEXAHEXBCYP2D6FTOMEN1 | |
| Amonafide SCHEMBL27226 | 0.83 | FTO (1.00) | HEXAHEXBCYP2D6FTOMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20130005759-A1 | SMALL MOLECULE MODIFIERS OF MICRORNA MIR-122 | NORTH CAROLINA STATE UNIVERSITY | 2013-01-03 | — | — | US | claimed |
| US-20130005759-A1 | SMALL MOLECULE MODIFIERS OF MICRORNA MIR-122 | NORTH CAROLINA STATE UNIVERSITY | 2013-01-03 | — | — | US | disclosed |
| US-20130005759-A1 | SMALL MOLECULE MODIFIERS OF MICRORNA MIR-122 | NORTH CAROLINA STATE UNIVERSITY | 2013-01-03 | — | — | US | disclosed |
| US-20130005759-A1 | SMALL MOLECULE MODIFIERS OF MICRORNA MIR-122 | NORTH CAROLINA STATE UNIVERSITY | 2013-01-03 | — | — | US | disclosed |
| WO-2011091209-A1 | SMALL MOLECULE MODIFIERS OF MICRORNA MIR-122 | NORTH CAROLINA STATE UNIVERSITY (US) | 2011-07-28 | — | — | WO | disclosed |
| WO-2011091209-A1 | SMALL MOLECULE MODIFIERS OF MICRORNA MIR-122 | NORTH CAROLINA STATE UNIVERSITY (US) | 2011-07-28 | — | — | WO | disclosed |
| US-20090156630-A1 | ANTI-TUMOUR POLYCYCLIC CARBOXAMIDES | BAGULEY BRUCE CHARLES | 2009-06-18 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090156630-A1 | ANTI-TUMOUR POLYCYCLIC CARBOXAMIDES | MKI67, MCL1, CCNI | HEXA 1669/4885HEXB 2371/4885CYP2D6 1584/4885 |
| US-20130005759-A1 | SMALL MOLECULE MODIFIERS OF MICRORNA MIR-122 | HAVCR2, CCAR2, EIF2AK2 | HEXA 3252/4885HEXB 3075/4885CYP2D6 2330/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.