Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FPR2 | P25090 | 2/20 | 0.50 |
| ▸ | PROKR1 | Q8TCW9 | 2/20 | 0.50 |
| ▸ | ENPP3 | O14638 | 1/20 | 0.42 |
| ▸ | ALPL | P05186 | 1/20 | 0.42 |
| ▸ | ENPP1 | P22413 | 1/20 | 0.42 |
| ▸ | XIAP | P98170 | 1/20 | 0.42 |
| ▸ | MEN1 | O00255 | 2/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | HPGD | P15428 | 1/20 | 0.40 |
| ▸ | SCN9A | Q15858 | 3/20 | 0.38 |
| ▸ | LPAR2 | Q9HBW0 | 3/20 | 0.38 |
| ▸ | MAPT | P10636 | 2/20 | 0.37 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.37 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.37 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.37 |
| ▸ | SLC22A12 | Q96S37 | 3/20 | 0.37 |
| ▸ | EPAS1 | Q99814 | 1/20 | 0.37 |
| ▸ | SYK | P43405 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6625485 | 0.74 | NOS2 (0.38) | FPR2PROKR1MEN1KMT2AKDM4E | |
| SCHEMBL6418878 | 0.71 | ENPP3 (0.59) | FPR2PROKR1ENPP3ALPLENPP1 | |
| SCHEMBL509165 | 0.71 | KCNH2 (0.58) | ENPP3ALPLENPP1XIAPKMT2A | |
| SCHEMBL945003 | 0.69 | ALDH1A1 (0.61) | KDM4EALDH1A1HPGD | |
| SCHEMBL29615609 | 0.69 | ALDH1A1 (0.61) | KDM4EALDH1A1HPGD | |
| SCHEMBL509030 | 0.68 | ENPP3 (0.55) | ENPP3ALPLENPP1XIAPMEN1 | |
| SCHEMBL4104852 | 0.68 | ENPP3 (0.55) | ENPP3ALPLENPP1XIAPMEN1 | |
| SCHEMBL4718347 | 0.68 | KCNH2 (0.54) | ENPP3ALPLENPP1XIAPMEN1 | |
| SCHEMBL31441456 | 0.68 | MAOA (0.61) | MEN1KMT2AKDM4EALDH1A1HPGD | |
| SCHEMBL7050401 | 0.68 | MAOA (0.61) | MEN1KMT2AKDM4EALDH1A1HPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1551828-A1 | PYRAZOLE DERIVATIVES | Pfizer Limited (GB) | 2005-07-13 | — | — | EP | disclosed |
| WO-2004031178-A1 | PYRAZOLE DERIVATIVES | PFIZER LIMITED (GB) | 2004-04-15 | — | — | WO | disclosed |