SCHEMBL6265992

SCHEMBL6265992

COc1cccc(-c2cc(Cl)c[c]c2Cl)c1

nearest known ligand 0.47

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
DYRK1A Q13627 1/20 0.47
CLK4 Q9HAZ1 1/20 0.47
MAOB P27338 1/20 0.46
CNR1 P21554 1/20 0.45
CYP1A1 P04798 2/20 0.44
CYP1A2 P05177 2/20 0.44
CYP2E1 P05181 2/20 0.44
CYP3A4 P08684 2/20 0.44
CYP2C8 P10632 2/20 0.44
CYP2D6 P10635 2/20 0.44
CYP2A6 P11509 2/20 0.44
CYP2C9 P11712 2/20 0.44
CYP4B1 P13584 2/20 0.44
CYP2B6 P20813 2/20 0.44
CYP3A5 P20815 2/20 0.44
CYP2A7 P20853 2/20 0.44
CYP3A7 P24462 2/20 0.44
CYP2F1 P24903 2/20 0.44
CYP2C18 P33260 2/20 0.44
CYP2C19 P33261 2/20 0.44

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL17514695 0.84 ABL1 (0.43) CYP1A1CYP1A2CYP2E1CYP3A4CYP2C8
SCHEMBL4275014 0.81 GAPDH (0.47) MAOBCNR1CYP3A4ALDH1A1LMNA
SCHEMBL4283150 0.81 DYRK1A (0.47) DYRK1ACLK4MAOBCYP1A1CYP1A2
SCHEMBL27880945 0.77 CNR1 (0.45) DYRK1ACLK4MAOBCNR1CYP1A1
SCHEMBL27985724 0.77 BACE1 (0.42) ALDH1A1HDAC8
SCHEMBL8309137 0.76 PRKAB2 (0.45) DYRK1ACLK4MAOBCYP1A1CYP1A2
SCHEMBL16574039 0.75 MAOB (0.53) DYRK1ACLK4MAOBCNR1CYP1A1
SCHEMBL20777074 0.75 MAOB (0.53) DYRK1ACLK4MAOBCNR1CYP1A1
SCHEMBL4608809 0.75 METAP2 (0.34) PDE4A
SCHEMBL4284888 0.75 HSD17B1 (0.45) CNR1CYP1A2CYP3A4CYP2D6CYP2C9

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2005100301-A1 2-ARYLOXYETHYL GLYCINE DERIVATIVES AND THEIR USE AS GLYCINE TRANSPORT INHIBITORS ELI LILLY AND COMPANY (US) 2005-10-27 WO claimed
WO-2005100301-A1 2-ARYLOXYETHYL GLYCINE DERIVATIVES AND THEIR USE AS GLYCINE TRANSPORT INHIBITORS ELI LILLY AND COMPANY (US) 2005-10-27 WO disclosed
EP-0892795-A1 PIPERIDINYLPYRAMIDINE DERIVATIVES SUMITOMO PHARMACEUTICALS COMPANY, LIMITED (JP) 1999-01-27 EP disclosed
WO-1997038992-A1 PIPERIDINYLPYRAMIDINE DERIVATIVES SUMITOMO PHARMACEUTICALS COMPANY, LIMITED (JP) 1997-10-23 WO disclosed