Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMARCA2 | P51531 | 1/20 | 0.49 |
| ▸ | SMARCA4 | P51532 | 1/20 | 0.49 |
| ▸ | PBRM1 | Q86U86 | 1/20 | 0.49 |
| ▸ | CKS1B | P61024 | 2/20 | 0.47 |
| ▸ | SKP1 | P63208 | 2/20 | 0.47 |
| ▸ | SKP2 | Q13309 | 2/20 | 0.47 |
| ▸ | BACE1 | P56817 | 5/20 | 0.46 |
| ▸ | PDK2 | Q15119 | 1/20 | 0.46 |
| ▸ | GPR119 | Q8TDV5 | 3/20 | 0.45 |
| ▸ | AKT1 | P31749 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.44 |
| ▸ | LMNA | P02545 | 1/20 | 0.44 |
| ▸ | MAPT | P10636 | 1/20 | 0.44 |
| ▸ | NAMPT | P43490 | 1/20 | 0.43 |
| ▸ | KIT | P10721 | 1/20 | 0.42 |
| ▸ | POLB | P06746 | 1/20 | 0.42 |
| ▸ | GAA | P10253 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20818663 | 0.87 | CKS1B (0.58) | SMARCA2SMARCA4PBRM1CKS1BSKP1 | |
| SCHEMBL29707355 | 0.86 | CKS1B (0.50) | SMARCA2SMARCA4PBRM1CKS1BSKP1 | |
| SCHEMBL6253535 | 0.84 | GPR119 (0.53) | SMARCA2SMARCA4PBRM1CKS1BSKP1 | |
| SCHEMBL209802 | 0.81 | MAPT (0.64) | PDK2GPR119ALDH1A1LMNAMAPT | |
| SCHEMBL114482 | 0.80 | GPR119 (0.53) | SMARCA2SMARCA4PBRM1CKS1BSKP1 | |
| SCHEMBL22579225 | 0.80 | MAPT (0.51) | PDK2GPR119ALDH1A1LMNAMAPT | |
| SCHEMBL12595780 | 0.79 | ALDH1A1 (0.59) | SMARCA2SMARCA4PBRM1GPR119ALDH1A1 | |
| SCHEMBL30479010 | 0.78 | ALDH1A1 (0.58) | SMARCA2SMARCA4PBRM1PDK2GPR119 | |
| SCHEMBL355504 | 0.78 | ALDH1A1 (0.58) | SMARCA2SMARCA4PBRM1PDK2GPR119 | |
| SCHEMBL6228319 | 0.78 | GPR119 (0.49) | SMARCA2SMARCA4PBRM1CKS1BSKP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1592772-A2 | 5HT7 ANTAGONISTS AND INVERSE AGONISTS | Pfizer Products Incorporated (US) | 2005-11-09 | — | — | EP | disclosed |
| US-20040229874-A1 | 5HT7 Antagonists and inverse agonists | PFIZER INC. | 2004-11-18 | — | — | US | disclosed |
| WO-2004067703-A2 | 5HT7 ANTAGONISTS AND INVERSE AGONISTS | PFIZER PRODUCTS INC. (US) | 2004-08-12 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040229874-A1 | 5HT7 Antagonists and inverse agonists | HTR7, HTR1A, HTR1B | SMARCA2 4569/4885SMARCA4 4431/4885PBRM1 3895/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.