Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR2C | P28335 | 11/20 | 0.55 |
| ▸ | HTR2A | P28223 | 9/20 | 0.55 |
| ▸ | HTR2B | P41595 | 8/20 | 0.55 |
| ▸ | PARP1 | P09874 | 2/20 | 0.46 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.42 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.39 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.39 |
| ▸ | CYP3A5 | P20815 | 2/20 | 0.39 |
| ▸ | CYP3A7 | P24462 | 2/20 | 0.39 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.39 |
| ▸ | PDK4 | Q16654 | 2/20 | 0.39 |
| ▸ | CYP3A43 | Q9HB55 | 2/20 | 0.39 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.38 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.38 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.38 |
| ▸ | OGFRL1 | Q5TC84 | 1/20 | 0.38 |
| ▸ | HTR1A | P08908 | 1/20 | 0.36 |
| ▸ | HTR7 | P34969 | 1/20 | 0.36 |
| ▸ | HTR5A | P47898 | 1/20 | 0.36 |
| ▸ | HTR6 | P50406 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16801723 | 0.75 | OPRM1 (0.65) | HTR2CHTR2AHTR2BOPRM1OPRD1 | |
| SCHEMBL1976916 | 0.74 | PARP1 (0.56) | HTR2CHTR2AHTR2BPARP1 | |
| SCHEMBL9280480 | 0.71 | HTR2C (0.56) | HTR2CHTR2AHTR2BPARP1CYP1A2 | |
| SCHEMBL15848120 | 0.71 | DRD2 (0.58) | HTR2CHTR2AHTR2BCYP1A2CYP3A4 | |
| SCHEMBL28538509 | 0.71 | HTR2C (0.40) | HTR2CHTR2AHTR2BPARP1OPRM1 | |
| SCHEMBL13965433 | 0.71 | HTR2C (1.00) | HTR2CHTR2AHTR2BPARP1 | |
| SCHEMBL13965425 | 0.71 | HTR2C (1.00) | HTR2CHTR2AHTR2BPARP1 | |
| SCHEMBL13966033 | 0.71 | HTR2C (1.00) | HTR2CHTR2AHTR2BPARP1 | |
| SCHEMBL31352052 | 0.70 | CYP1A2 (0.49) | HTR2CHTR2AHTR2BCYP1A2CYP3A4 | |
| SCHEMBL3440231 | 0.70 | CYP1A2 (0.49) | HTR2CHTR2AHTR2BCYP1A2CYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20050228023-A1 | Agonist and antagonist ligands of the nociceptin receptor | SRI INTERNATIONAL (US) | 2005-10-13 | — | — | US | disclosed |
| WO-2005060947-A2 | AGONIST AND ANTAGONIST LIGANDS OF THE NOCICEPTIN RECEPTOR | SRI INTERNATIONAL (US) | 2005-07-07 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050228023-A1 | Agonist and antagonist ligands of the nociceptin receptor | OPRL1, OPRK1, OPRM1 | HTR2C 33/4885HTR2A 15/4885HTR2B 57/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.