Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | THRB | P10828 | 9/20 | 0.60 |
| ▸ | THRA | P10827 | 5/20 | 0.60 |
| ▸ | RORC | P51449 | 11/20 | 0.51 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.43 |
| ▸ | NPC1 | O15118 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.43 |
| ▸ | LMNA | P02545 | 1/20 | 0.43 |
| ▸ | HPGD | P15428 | 1/20 | 0.43 |
| ▸ | HTT | P42858 | 1/20 | 0.43 |
| ▸ | RAB9A | P51151 | 1/20 | 0.43 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.43 |
| ▸ | NPBWR1 | P48145 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6275907 | 0.89 | THRA (0.77) | THRBTHRA | |
| SCHEMBL6368421 | 0.80 | RORC (0.64) | THRBTHRARORCRAB9A | |
| SCHEMBL7088325 | 0.80 | ALOX15 (0.50) | THRBTHRAKDM4ENPC1ALDH1A1 | |
| SCHEMBL6818010 | 0.79 | KDM4E (0.67) | KDM4ENPC1ALDH1A1LMNAHPGD | |
| SCHEMBL6274126 | 0.77 | THRB (0.55) | THRBTHRAKDM4ENPC1ALDH1A1 | |
| SCHEMBL6270954 | 0.77 | THRB (0.54) | THRBTHRAKDM4ENPC1ALDH1A1 | |
| SCHEMBL1642096 | 0.75 | THRA (1.00) | THRBTHRA | |
| SCHEMBL6594500 | 0.75 | ALDH1A1 (0.55) | KDM4ENPC1ALDH1A1LMNAHPGD | |
| SCHEMBL14264314 | 0.74 | THRB (0.61) | THRBTHRARORCHPGD | |
| SCHEMBL6270951 | 0.73 | THRA (0.60) | THRBTHRA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1297833-B1 | Indole carboxylic acids as thyroid receptor ligands | PFIZER PROD INC (US) | 2005-12-21 | — | — | EP | disclosed |
| US-6723744-B2 | FOR THERAPY OF OBESITY, OVERWEIGHT CONDITION, HYPERLIPIDEMIA, GLAUCOMA, CARDIAC ARRHYTHMIAS, SKIN DISORDER, THYROID DISEASE, HYPOTHYROIDISM, THYROID CANCER, DIABETES, ATHEROSCLEROSIS, HYPERTENSION, CORONARY HEART DISEASE, HYPERCHOLESTEREMIA | PFIZER, INC. | 2004-04-20 | — | — | US | disclosed |
| WO-2004018421-A1 | IDOL DERIVATIVES AS NEW THYROID RECEPTOR AGONIST LIGANDS AND METHODS | KARO BIO AB. (SE) | 2004-03-04 | — | — | WO | disclosed |
| US-20030078289-A1 | Indole carboxylic acids as thyroid receptor ligands | ASPNES GARY E (US) | 2003-04-24 | — | — | US | disclosed |
| EP-1297833-A1 | Indole carboxylic acids as thyroid receptor ligands | Pfizer Products Inc. (US) | 2003-04-02 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20030078289-A1 | Indole carboxylic acids as thyroid receptor ligands | THRA, MC1R, THRB | THRB 3/4885THRA 1/4885RORC 619/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.