Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BCL2 | P10415 | 6/20 | 0.34 |
| ▸ | GSTP1 | P09211 | 1/20 | 0.32 |
| ▸ | GSTM2 | P28161 | 1/20 | 0.32 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.32 |
| ▸ | SCN9A | Q15858 | 2/20 | 0.31 |
| ▸ | ACHE | P22303 | 1/20 | 0.31 |
| ▸ | PPARG | P37231 | 1/20 | 0.30 |
| ▸ | PPARA | Q07869 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6211337 | 0.90 | GSK3A (0.33) | BCL2 | |
| SCHEMBL2909660 | 0.84 | BCL2 (0.33) | BCL2GSTP1GSTM2MCL1SCN9A | |
| SCHEMBL6209893 | 0.78 | ALDH1A1 (0.32) | — | |
| SCHEMBL2909547 | 0.78 | GSK3B (0.37) | — | |
| Hydrochloric Acid SCHEMBL2911853 | 0.77 | KAT2B (0.37) | — | |
| SCHEMBL2907603 | 0.75 | CA2 (0.35) | BCL2 | |
| SCHEMBL2912738 | 0.74 | BCL2 (0.32) | BCL2GSTP1GSTM2MCL1SCN9A | |
| SCHEMBL2907410 | 0.73 | GSK3B (0.34) | — | |
| SCHEMBL2907714 | 0.71 | GSK3B (0.42) | BCL2GSTP1GSTM2MCL1 | |
| SCHEMBL2905411 | 0.70 | GSK3B (0.35) | ACHE |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1537099-A1 | PYRROLE BASED INHIBITORS OF GLYCOGEN SYNTHASE KINASE 3 | CHIRON CORPORATION (US) | 2005-06-08 | — | — | EP | disclosed |
| WO-2004018455-A1 | PYRROLE BASED INHIBITORS OF GLYCOGEN SYNTHASE KINASE 3 | CHIRON CORPORATION (US) | 2004-03-04 | — | — | WO | disclosed |