Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PGR | P06401 | 20/20 | 1.00 |
| ▸ | AR | P10275 | 3/20 | 0.60 |
| ▸ | NR3C1 | P04150 | 2/20 | 0.59 |
| ▸ | NR3C2 | P08235 | 2/20 | 0.59 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL64275 | 0.85 | PGR (0.74) | PGRNR3C1 | |
| SCHEMBL3985849 | 0.82 | PGR (1.00) | PGR | |
| SCHEMBL4911165 | 0.81 | PGR (0.68) | PGRARNR3C1NR3C2 | |
| SCHEMBL1223269 | 0.81 | PGR (0.67) | PGR | |
| SCHEMBL1223201 | 0.80 | PGR (0.66) | PGRARNR3C1NR3C2 | |
| SCHEMBL1223217 | 0.80 | PGR (0.66) | PGRARNR3C1NR3C2 | |
| SCHEMBL1223876 | 0.80 | PGR (0.66) | PGRARNR3C1NR3C2 | |
| SCHEMBL3872645 | 0.79 | PGR (1.00) | PGRARNR3C1NR3C2 | |
| SCHEMBL3883683 | 0.78 | PGR (0.86) | PGRARNR3C1NR3C2 | |
| SCHEMBL4009026 | 0.78 | PGR (0.69) | PGR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 50 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8476262-B2 | Cyanopyrroles | WYETH LLC (US) | 2013-07-02 | — | — | US | claimed |
| US-20110039839-A1 | Cyanopyrroles | WYETH LLC (US) | 2011-02-17 | — | — | US | claimed |
| US-20090054663-A1 | COUPLING PROCESS FOR GENERATING REACTIVE BORON-CONTAINING DERIVATIVES OF N-SUBSTITUTED PYRROLE-2-CARBONITRILES TO PRODUCE BIARYLS | WYETH (US) | 2009-02-26 | — | — | US | claimed |
| EP-1173433-B1 | CYANOPYRROLES AS PROGESTERONE RECEPTOR AGONISTS | WYETH CORP (US) | 2005-12-28 | — | — | EP | claimed |
| US-20050272702-A1 | Coupling process for generating reactive boron-containing derivatives of N-substituted pyrrole-2-carbonitriles to produce biaryls | WYETH (US) | 2005-12-08 | — | — | US | claimed |
| US-20050256110-A1 | Cyanopyrroles | WYETH (US) | 2005-11-17 | — | — | US | claimed |
| CN-1133635-C | Cyanopyrroles for binding progesterone receptors | �Ʒ� | 2004-01-07 | — | — | CN | claimed |
| US-6407101-B1 | PROGESTERONE RECEPTOR ANTAGONISTS; CONTRACEPTIVES, HORMONE REPLACEMENT THERAPY; BREAST AND PROSTATE CANCER TREATMENT; MENOPAUSE | AMERICAN HOME PRODUCTS CORPORATION | 2002-06-18 | — | — | US | claimed |
| CN-1349531-A | Cyanopyrroles as progesterone receptor agonists | AMERICAN HOME PROD (US) | 2002-05-15 | — | — | CN | claimed |
| WO-2014159377-A1 | COMPOSITIONS CONTAINING TANAPROGET AND NATURAL ESTROGENS | TEVA WOMEN'S HEALTH, INC. (US) | 2014-10-02 | — | — | WO | disclosed |
| US-8796266-B2 | Cyclothiocarbamate derivatives as progesterone receptor modulators | WYETH LLC (US) | 2014-08-05 | — | — | US | disclosed |
| US-20130261112-A1 | Cyclothiocarbamate Derivatives as Progesterone Receptor Modulators | WYETH LLC | 2013-10-03 | — | — | US | disclosed |
| EP-1874743-B1 | PURIFIED FORM OF TANAPROGET | WYETH LLC (US) | 2013-07-17 | — | — | EP | disclosed |
| US-8476262-B2 | Cyanopyrroles | WYETH LLC (US) | 2013-07-02 | — | — | US | disclosed |
| US-6562857-B2 | Progesterone receptor antagonist; inhibiting breast, uterine, ovarian, endometrial, or prostate cancer | WYETH | 2003-05-13 | — | — | US | disclosed |
| US-6436929-B1 | 3,1-BENZOXAZINE-2-THIONES; CONTRACEPTION AND THE TREATMENT OF PROGESTERONE-RELATED MALADIES | WYETH | 2002-08-20 | — | — | US | disclosed |
| US-6407101-B1 | PROGESTERONE RECEPTOR ANTAGONISTS; CONTRACEPTIVES, HORMONE REPLACEMENT THERAPY; BREAST AND PROSTATE CANCER TREATMENT; MENOPAUSE | AMERICAN HOME PRODUCTS CORPORATION | 2002-06-18 | — | — | US | disclosed |
| US-20020068735-A1 | Cyanopyrroles | AMERICAN HOME PRODUCTS CORPORATION | 2002-06-06 | — | — | US | disclosed |
| CN-1349531-A | Cyanopyrroles as progesterone receptor agonists | AMERICAN HOME PROD (US) | 2002-05-15 | — | — | CN | disclosed |
| CN-1349516-A | Cyclothiocarbamate derivatives as progesterone receptor modulators | AMERICAN HOME PROD (US) | 2002-05-15 | — | — | CN | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (6 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050256110-A1 | Cyanopyrroles | PGR, MC2R, THRB | PGR 1/4885AR 28/4885NR3C1 22/4885 |
| US-20090054663-A1 | COUPLING PROCESS FOR GENERATING REACTIVE BORON-CONTAINING DERIVATIVES OF N-SUBSTITUTED PYRROLE-2-CARBONITRILES TO PRODUCE BIARYLS | BOLA2; BOLA2B, BRI3BP, BROX | PGR 1401/4885AR 3276/4885NR3C1 2069/4885 |
| US-20110039839-A1 | Cyanopyrroles | PGR, MC2R, THRB | PGR 1/4885AR 28/4885NR3C1 22/4885 |
| US-20020068735-A1 | Cyanopyrroles | PGR, NR3C2, GNRHR | PGR 1/4885AR 28/4885NR3C1 19/4885 |
| US-20130261112-A1 | Cyclothiocarbamate Derivatives as Progesterone Receptor Modulators | PGR, PGRMC2, PGRMC1 | PGR 1/4885AR 97/4885NR3C1 17/4885 |
| US-20050272702-A1 | Coupling process for generating reactive boron-containing derivatives of N-substituted pyrrole-2-carbonitriles to produce biaryls | BOLA2; BOLA2B, BRI3BP, BROX | PGR 1401/4885AR 3276/4885NR3C1 2069/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.