Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4A | P27815 | 7/20 | 0.49 |
| ▸ | ADORA2A | P29274 | 7/20 | 0.49 |
| ▸ | PDE4B | Q07343 | 7/20 | 0.49 |
| ▸ | PDE4C | Q08493 | 7/20 | 0.49 |
| ▸ | PDE4D | Q08499 | 7/20 | 0.49 |
| ▸ | ADORA2B | P29275 | 5/20 | 0.49 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.49 |
| ▸ | USP2 | O75604 | 3/20 | 0.44 |
| ▸ | POLB | P06746 | 3/20 | 0.44 |
| ▸ | MEN1 | O00255 | 2/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.44 |
| ▸ | KEAP1 | Q14145 | 2/20 | 0.44 |
| ▸ | NFE2L2 | Q16236 | 2/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.44 |
| ▸ | RGS12 | O14924 | 1/20 | 0.44 |
| ▸ | NPC1 | O15118 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.44 |
| ▸ | RAB9A | P51151 | 1/20 | 0.44 |
| ▸ | BLM | P54132 | 1/20 | 0.44 |
| ▸ | CACNA1B | Q00975 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8522266 | 0.96 | ADORA2B (0.51) | PDE4AADORA2APDE4BPDE4CPDE4D | |
| SCHEMBL6272293 | 0.95 | ADORA2B (0.53) | PDE4AADORA2APDE4BPDE4CPDE4D | |
| SCHEMBL4384737 | 0.95 | ADORA2B (0.53) | PDE4AADORA2APDE4BPDE4CPDE4D | |
| SCHEMBL8536000 | 0.95 | ADORA2B (0.53) | PDE4AADORA2APDE4BPDE4CPDE4D | |
| Hydrochloric Acid SCHEMBL258895 | 0.93 | ADORA2B (0.52) | PDE4AADORA2APDE4BPDE4CPDE4D | |
| SCHEMBL667794 | 0.92 | PDE4A (0.49) | PDE4AADORA2APDE4BPDE4CPDE4D | |
| Acetic Acid SCHEMBL4280715 | 0.89 | ADORA2B (0.48) | PDE4AADORA2APDE4BPDE4CPDE4D | |
| SCHEMBL8196740 | 0.86 | ADORA2B (0.37) | PDE4AADORA2APDE4BPDE4CPDE4D | |
| SCHEMBL874734 | 0.85 | ADORA2A (0.45) | PDE4AADORA2APDE4BPDE4CPDE4D | |
| SCHEMBL3671337 | 0.83 | PNP (0.37) | PDE4AADORA2APDE4BPDE4CPDE4D |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 11 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1017394-B1 | CYCLIN DEPENDENT KINASE INHIBITING PURINE DERIVATIVES | CANCER REC TECH LTD (GB) | 2005-12-07 | — | — | EP | disclosed |
| EP-1230267-A2 | MEMBRANE TRANSLOCATING PEPTIDE DRUG DELIVERY SYSTEM | O'Mahony, Daniel J. (IE) | 2002-08-14 | — | — | EP | disclosed |
| US-6303618-B1 | ADMINISTERING PURINE COMPOUND WHICH INHIBITS CYCLIC DEPENDENT KINASE ACTIVITY FOR THERAPY OF TUMOR OR OTHER CELL PROLIFERATION DISORDER | CANCER RESEARCH CAMPAIGN TECHNOLOGY LIMITED (GB) | 2001-10-16 | — | — | US | disclosed |
| CN-1067073-C | Acyclic nucleoside derivatives | MEDIVIR AB (CH) | 2001-06-13 | — | — | CN | disclosed |
| WO-2001027154-A2 | MEMBRANE TRANSLOCATING PEPTIDE DRUG DELIVERY SYSTEM | MAHONY DANIEL J O (IE) | 2001-04-19 | — | — | WO | disclosed |
| CN-1210537-A | Acyclic nucleoside derivatives | MEDIVIR AB (CH) | 1999-03-10 | — | — | CN | disclosed |
| EP-0523100-A4 | O?6 -BENZYLATED GUANINE, GUANOSINE AND 2'-DEOXYGUANOSINE COMPOUNDS POSSESSING O?6 -ALKYLGUANINE-DNA ALKYLTRANSFERASE DEPLETING ACTIVITY | US HEALTH (US) | 1993-03-17 | — | — | EP | disclosed |
| EP-0523100-A1 | O?6 -BENZYLATED GUANINE, GUANOSINE AND 2'-DEOXYGUANOSINE COMPOUNDS POSSESSING O?6 -ALKYLGUANINE-DNA ALKYLTRANSFERASE DEPLETING ACTIVITY. | US HEALTH (US) | 1993-01-20 | — | — | EP | disclosed |
| WO-1991013898-A1 | O6-BENZYLATED GUANINE, GUANOSINE AND 2'-DEOXYGUANOSINE COMPOUNDS POSSESSING O6-ALKYLGUANINE-DNA ALKYLTRANSFERASE DEPLETING ACTIVITY | THE UNITED STATES OF AMERICA, REPRESENTED BY THE SECRETARY, UNITED STATES DEPARTMENT OF COMMERCE (US) | 1991-09-19 | — | — | WO | disclosed |
| EP-0152316-B1 | SUBSTITUTED BUTYL GUANINES AND THEIR UTILIZATION IN ANTIVIRAL COMPOSITIONS | MERCK & CO. INC. (US) | 1989-07-26 | — | — | EP | disclosed |
| EP-0152316-A1 | Substituted butyl guanines and their utilization in antiviral compositions | MERCK & CO. INC. (US) | 1985-08-21 | — | — | EP | disclosed |