Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADORA2B | P29275 | 3/20 | 0.51 |
| ▸ | PNP | P00491 | 1/20 | 0.46 |
| ▸ | PDE4A | P27815 | 5/20 | 0.45 |
| ▸ | ADORA2A | P29274 | 5/20 | 0.45 |
| ▸ | PDE4B | Q07343 | 5/20 | 0.45 |
| ▸ | PDE4C | Q08493 | 5/20 | 0.45 |
| ▸ | PDE4D | Q08499 | 5/20 | 0.45 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.45 |
| ▸ | TLR8 | Q9NR97 | 7/20 | 0.44 |
| ▸ | USP2 | O75604 | 3/20 | 0.44 |
| ▸ | POLB | P06746 | 3/20 | 0.44 |
| ▸ | MEN1 | O00255 | 2/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.44 |
| ▸ | KEAP1 | Q14145 | 2/20 | 0.44 |
| ▸ | NFE2L2 | Q16236 | 2/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.44 |
| ▸ | MAPT | P10636 | 1/20 | 0.44 |
| ▸ | HTT | P42858 | 1/20 | 0.44 |
| ▸ | PKM | P14618 | 1/20 | 0.44 |
| ▸ | HPGD | P15428 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4384737 | 0.99 | ADORA2B (0.53) | ADORA2BPNPPDE4AADORA2APDE4B | |
| SCHEMBL8536000 | 0.99 | ADORA2B (0.53) | ADORA2BPNPPDE4AADORA2APDE4B | |
| SCHEMBL6272293 | 0.99 | ADORA2B (0.53) | ADORA2BPNPPDE4AADORA2APDE4B | |
| Hydrochloric Acid SCHEMBL258895 | 0.97 | ADORA2B (0.52) | ADORA2BPNPPDE4AADORA2APDE4B | |
| SCHEMBL6272726 | 0.96 | PDE4A (0.49) | ADORA2BPNPPDE4AADORA2APDE4B | |
| Acetic Acid SCHEMBL4280715 | 0.93 | ADORA2B (0.48) | ADORA2BPNPPDE4AADORA2APDE4B | |
| SCHEMBL667794 | 0.90 | PDE4A (0.49) | ADORA2BPDE4AADORA2APDE4BPDE4C | |
| SCHEMBL8196740 | 0.88 | ADORA2B (0.37) | ADORA2BPNPPDE4AADORA2APDE4B | |
| SCHEMBL874734 | 0.84 | ADORA2A (0.45) | ADORA2BPNPPDE4AADORA2APDE4B | |
| SCHEMBL3671337 | 0.82 | PNP (0.37) | ADORA2BPNPPDE4AADORA2APDE4B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 11 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-116234585-A | Microtubule-associated protein TAU (MAPT) iRNA agent compositions and methods of use thereof | 阿尔尼拉姆医药品有限公司 | 2023-06-06 | — | — | CN | disclosed |
| CN-115298312-A | Leucine-rich repeat kinase 2 (LRRK 2) iRNA agent compositions and methods of use thereof | 阿尔尼拉姆医药品有限公司 | 2022-11-04 | — | — | CN | disclosed |
| CN-114796255-A | Application of nicotinamide mononucleotide in protecting liver from being damaged | 深圳市旷逸生物科技有限公司 | 2022-07-29 | — | — | CN | disclosed |
| CN-114728018-A | Huntington (HTT) iRNA pharmaceutical compositions and methods of use thereof | 阿尔尼拉姆医药品有限公司 | 2022-07-08 | — | — | CN | disclosed |
| EP-0704445-B1 | Preparation of N-9 substituted guanine compounds | HOFFMANN LA ROCHE (CH) | 1999-04-21 | — | — | EP | disclosed |
| US-5565565-A | Preparation of N-9 substituted guanine compounds | SYNTEX (U.S.A.) INC. (US) | 1996-10-15 | — | — | US | disclosed |
| EP-0704445-A1 | Preparation of N-9 substituted guanine compounds | F. Hoffmann-La Roche AG (CH) | 1996-04-03 | — | — | EP | disclosed |
| EP-0590361-A1 | Process for the preparation of 2-amino-6-halopurines | BASF Aktiengesellschaft (DE) | 1994-04-06 | — | — | EP | disclosed |
| US-4914131-A | HERPES SIMPLEX VIRUS; LIDOCAINE OR ITS SALTS | Brigham, Dana P. (US) | 1990-04-03 | — | — | US | disclosed |
| US-4757088-A | Administering lidocaine and pantothenic acid; herpes | Brigham, Dana P. (US) | 1988-07-12 | — | — | US | disclosed |
| US-4628063-A | LIDOCAINE, PANTOTHENOL, HERPES | Brigham, Dana P. (US) | 1986-12-09 | — | — | US | disclosed |