Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PNP | P00491 | 1/20 | 0.37 |
| ▸ | ADORA2A | P29274 | 9/20 | 0.33 |
| ▸ | PDE4A | P27815 | 9/20 | 0.33 |
| ▸ | PDE4B | Q07343 | 9/20 | 0.33 |
| ▸ | PDE4C | Q08493 | 9/20 | 0.33 |
| ▸ | PDE4D | Q08499 | 9/20 | 0.33 |
| ▸ | ADORA2B | P29275 | 8/20 | 0.33 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
| ▸ | ADORA3 | P0DMS8 | 3/20 | 0.32 |
| ▸ | PDE2A | O00408 | 1/20 | 0.31 |
| ▸ | PDE5A | O76074 | 1/20 | 0.31 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.31 |
| ▸ | CFTR | P13569 | 1/20 | 0.31 |
| ▸ | TSHR | P16473 | 1/20 | 0.31 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.31 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.31 |
| ▸ | SCN1A | P35498 | 1/20 | 0.31 |
| ▸ | PDE6C | P51160 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL667794 | 0.85 | PDE4A (0.49) | ADORA2APDE4APDE4BPDE4CPDE4D | |
| SCHEMBL9960806 | 0.84 | PNP (0.38) | PNPADORA2APDE4APDE4BPDE4C | |
| SCHEMBL6272726 | 0.83 | PDE4A (0.49) | PNPADORA2APDE4APDE4BPDE4C | |
| SCHEMBL8196740 | 0.83 | ADORA2B (0.37) | PNPADORA2APDE4APDE4BPDE4C | |
| SCHEMBL874734 | 0.82 | ADORA2A (0.45) | PNPADORA2APDE4APDE4BPDE4C | |
| SCHEMBL8522266 | 0.82 | ADORA2B (0.51) | PNPADORA2APDE4APDE4BPDE4C | |
| SCHEMBL17186375 | 0.81 | KDM5B (0.39) | PNP | |
| SCHEMBL8536000 | 0.81 | ADORA2B (0.53) | PNPADORA2APDE4APDE4BPDE4C | |
| SCHEMBL17186419 | 0.81 | PIK3CA (0.35) | PNPADORA2APDE4APDE4BPDE4C | |
| SCHEMBL6272293 | 0.81 | ADORA2B (0.53) | PNPADORA2APDE4APDE4BPDE4C |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0910246-B1 | USE OF MUTANT ALKYLTRANSFERASES FOR GENE THERAPY TO PROTECT FROM TOXICITY OF THERAPEUTIC ALKYLATING AGENTS | PENN STATE RES FOUND (US) | 2010-08-18 | — | — | EP | disclosed |
| EP-0910246-A4 | USE OF MUTANT ALKYLTRANSFERASES FOR GENE THERAPY TO PROTECT FROM TOXICITY OF THERAPEUTIC ALKYLATING AGENTS | PENN STATE RES FOUND (US) | 2003-07-02 | — | — | EP | disclosed |
| EP-0910246-A1 | USE OF MUTANT ALKYLTRANSFERASES FOR GENE THERAPY TO PROTECT FROM TOXICITY OF THERAPEUTIC ALKYLATING AGENTS | THE PENN STATE RESEARCH FOUNDATION (US) | 1999-04-28 | — | — | EP | disclosed |
| WO-1997035477-A1 | USE OF MUTANT ALKYLTRANSFERASES FOR GENE THERAPY TO PROTECT FROM TOXICITY OF THERAPEUTIC ALKYLATING AGENTS | THE PENN STATE RESEARCH FOUNDATION (US) | 1997-10-02 | — | — | WO | disclosed |