Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CCR5 | P51681 | 4/20 | 0.40 |
| ▸ | OPRK1 | P41145 | 2/20 | 0.38 |
| ▸ | TACR1 | P25103 | 1/20 | 0.38 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.38 |
| ▸ | JAK2 | O60674 | 1/20 | 0.38 |
| ▸ | JAK1 | P23458 | 1/20 | 0.38 |
| ▸ | YAP1 | P46937 | 1/20 | 0.38 |
| ▸ | CCR1 | P32246 | 1/20 | 0.37 |
| ▸ | PARP1 | P09874 | 1/20 | 0.37 |
| ▸ | PARP2 | Q9UGN5 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6094257 | 1.00 | CCR5 (0.40) | CCR5OPRK1TACR1OPRD1JAK2 | |
| SCHEMBL6094255 | 1.00 | CCR5 (0.40) | CCR5OPRK1TACR1OPRD1JAK2 | |
| SCHEMBL8306441 | 1.00 | CCR5 (0.40) | CCR5OPRK1TACR1OPRD1JAK2 | |
| SCHEMBL6273386 | 1.00 | CCR5 (0.40) | CCR5OPRK1TACR1OPRD1JAK2 | |
| SCHEMBL8310994 | 0.92 | OPRD1 (0.40) | OPRK1TACR1OPRD1JAK2JAK1 | |
| SCHEMBL8312282 | 0.89 | YAP1 (0.41) | OPRK1OPRD1JAK2JAK1YAP1 | |
| SCHEMBL6094822 | 0.89 | YAP1 (0.41) | OPRK1OPRD1JAK2JAK1YAP1 | |
| SCHEMBL6094817 | 0.89 | YAP1 (0.41) | OPRK1OPRD1JAK2JAK1YAP1 | |
| SCHEMBL6094587 | 0.89 | CCR1 (0.40) | TACR1CCR1 | |
| SCHEMBL6096715 | 0.89 | CCR1 (0.40) | TACR1CCR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1605941-A1 | SUBSTITUTED PIPERIDINES AS NOVEL MDM2-p53 INHIBITORS | F. HOFFMANN-LA ROCHE AG (CH) | 2005-12-21 | — | — | EP | disclosed |
| WO-2004080460-A1 | SUBSTITUTED PIPERIDINES AS NOVEL MDM2-p53 INHIBITORS | F. HOFFMANN-LA ROCHE AG (CH) | 2004-09-23 | — | — | WO | disclosed |