Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | YAP1 | P46937 | 3/20 | 0.41 |
| ▸ | TP53 | P04637 | 2/20 | 0.39 |
| ▸ | TLR9 | Q9NR96 | 1/20 | 0.39 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.39 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.39 |
| ▸ | JAK2 | O60674 | 1/20 | 0.39 |
| ▸ | JAK1 | P23458 | 1/20 | 0.39 |
| ▸ | MDM2 | Q00987 | 1/20 | 0.38 |
| ▸ | CCR1 | P32246 | 1/20 | 0.38 |
| ▸ | GHSR | Q92847 | 1/20 | 0.38 |
| ▸ | PDE4A | P27815 | 2/20 | 0.38 |
| ▸ | PDE4B | Q07343 | 2/20 | 0.38 |
| ▸ | PDE4C | Q08493 | 2/20 | 0.38 |
| ▸ | PDE4D | Q08499 | 2/20 | 0.38 |
| ▸ | CTSD | P07339 | 1/20 | 0.38 |
| ▸ | CTSE | P14091 | 1/20 | 0.38 |
| ▸ | BACE1 | P56817 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6094822 | 1.00 | YAP1 (0.41) | YAP1TP53TLR9OPRD1OPRK1 | |
| SCHEMBL6094817 | 1.00 | YAP1 (0.41) | YAP1TP53TLR9OPRD1OPRK1 | |
| SCHEMBL8310994 | 0.93 | OPRD1 (0.40) | YAP1TP53OPRD1OPRK1JAK2 | |
| SCHEMBL8306441 | 0.89 | CCR5 (0.40) | YAP1OPRD1OPRK1JAK2JAK1 | |
| SCHEMBL6094255 | 0.89 | CCR5 (0.40) | YAP1OPRD1OPRK1JAK2JAK1 | |
| SCHEMBL6273383 | 0.89 | CCR5 (0.40) | YAP1OPRD1OPRK1JAK2JAK1 | |
| SCHEMBL6094257 | 0.89 | CCR5 (0.40) | YAP1OPRD1OPRK1JAK2JAK1 | |
| SCHEMBL6273386 | 0.89 | CCR5 (0.40) | YAP1OPRD1OPRK1JAK2JAK1 | |
| SCHEMBL14028090 | 0.82 | TACR1 (0.46) | YAP1OPRD1OPRK1JAK2JAK1 | |
| SCHEMBL6095983 | 0.79 | CXCR3 (0.42) | TP53MDM2CCR1ALDH1A1SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2004080460-A1 | SUBSTITUTED PIPERIDINES AS NOVEL MDM2-p53 INHIBITORS | F. HOFFMANN-LA ROCHE AG (CH) | 2004-09-23 | — | — | WO | disclosed |